{"id":"W4364374948","doi":"10.1200/jco.22.02661","title":"External Validation of a Prognostic Model of Overall Survival in Men With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of British Columbia; BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; Yale University; Celgene; AstraZeneca; Active Biotech; Bristol-Myers Squibb","keywords":"Docetaxel; Medicine; Prostate cancer; Oncology; Internal medicine; Overall survival; Chemotherapy; Cancer; Prognostic model; Castration; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01700653,0.001011493,0.0008330739,0.0008682482,0.000393696,0.001177328,0.0007693311,0.0005245921,0.0006767126],"category_scores_gemma":[0.03616652,0.0002018342,0.0009684976,0.0006257085,0.0007612682,0.0005490902,0.0009760411,0.001126272,0.0003198116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008645946,"about_ca_system_score_gemma":0.0013226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004847663,"about_ca_topic_score_gemma":0.00270484,"domain_scores_codex":[0.9956755,0.002763932,0.0001803306,0.000694706,0.0004855318,0.000199954],"domain_scores_gemma":[0.977675,0.01468837,0.002840346,0.002153448,0.002151906,0.0004908824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001356479,0.0002083472,0.8384482,0.00007404445,0.0006209755,0.0001112038,0.0001333883,0.1237148,0.0009035704,0.0003769964,0.001006465,0.03304555],"study_design_scores_gemma":[0.0001817576,0.001080655,0.2323425,0.0000933907,0.0003366652,0.0002635159,0.00008323365,0.7607296,0.001860294,0.001548985,0.00143493,0.00004456902],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627599,0.0005153436,0.03373469,0.0003411838,0.0000514511,0.0001444527,0.0009819138,0.0002309598,0.001240062],"genre_scores_gemma":[0.9955891,0.0000532938,0.003226097,0.00005276249,0.00002028964,0.00003279177,0.0008915167,0.00001230326,0.0001217617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01700653,"threshold_uncertainty_score":0.08994019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1925941619625423,"score_gpt":0.4940113362725537,"score_spread":0.3014171743100114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}