{"id":"W4364377006","doi":"10.3389/fonc.2023.1043694","title":"Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"International Development Research Centre; Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada; Leukemia and Lymphoma Society","keywords":"Ruxolitinib; Chronic lymphocytic leukemia; In vivo; In vitro; Cancer research; Leukemia; CD20; Medicine; Immunology; Chemistry; Biology; Bone marrow; Lymphoma; Genetics; Myelofibrosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003676562,0.000479959,0.0004565289,0.0004230273,0.0001824257,0.0004608648,0.0001673292,0.0003695752,0.004056859],"category_scores_gemma":[0.000198147,0.0001662828,0.0003077152,0.0002466998,0.0001550764,0.0002152384,0.0001998735,0.0007453709,0.000977803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002690156,"about_ca_system_score_gemma":0.0001916854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007615209,"about_ca_topic_score_gemma":0.0007925844,"domain_scores_codex":[0.999294,0.0002775139,0.00006568847,0.00008803167,0.0001311004,0.0001435385],"domain_scores_gemma":[0.9997697,0.00008782052,0.00004042942,0.00003988849,0.00002979375,0.00003232786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001002706,0.0003737107,0.0006083138,0.0002105937,0.00002165806,0.00007449456,0.00007691237,0.0001728953,0.9898139,0.000199485,0.0005185222,0.006926706],"study_design_scores_gemma":[0.0001648971,0.002644652,0.006907582,0.0000236887,0.00004436272,0.0004427196,0.00007645829,0.001882005,0.9822553,0.0001052197,0.005442613,0.00001049349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628319,0.01527118,0.007503935,0.000532659,0.0003145553,0.0001629142,0.002160933,0.0003639359,0.01085788],"genre_scores_gemma":[0.989292,0.001834221,0.00299204,0.0001609209,0.00007295853,0.0001879743,0.001581734,0.00001834682,0.003859852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004056859,"threshold_uncertainty_score":0.01357156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472581065652083,"score_gpt":0.3071507311629147,"score_spread":0.2924249205063939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}