{"id":"W4365133685","doi":"10.1038/s41586-023-05857-4","title":"Clonal haematopoiesis and risk of chronic liver disease","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":201,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; McGill University; University of Calgary; University of Saskatchewan; Université Laval; Université de Montréal; Providence Health Care","funders":"National Institute on Minority Health and Health Disparities; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute on Aging; Knut och Alice Wallenbergs Stiftelse; Cancer Research UK; Kay Kendall Leukaemia Fund; Fondation Leducq; Edward P. Evans Foundation; Gilead Sciences; National Institute of General Medical Sciences; Massachusetts General Hospital; AstraZeneca; National Heart, Lung, and Blood Institute; Pfizer; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; Deutsche Forschungsgemeinschaft; Alex's Lemonade Stand Foundation for Childhood Cancer; Damon Runyon Cancer Research Foundation; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Medicine; Chronic liver disease; Internal medicine; Odds ratio; Immunology; Gastroenterology; Cirrhosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004113707,0.00007428115,0.0001383715,0.00005686603,0.0000344438,0.000004521019,0.00002632376,0.0001655097,0.0001455153],"category_scores_gemma":[0.00005853739,0.0000531958,0.00008020406,0.0001348427,0.00004007139,0.00002678408,0.00003343271,0.0002769939,0.00004685262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000305547,"about_ca_system_score_gemma":0.0000730376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002582201,"about_ca_topic_score_gemma":0.000009330815,"domain_scores_codex":[0.9994909,0.00001551364,0.00006980007,0.0001442573,0.0001770083,0.0001024757],"domain_scores_gemma":[0.9995574,0.00006375791,0.00003193133,0.0001493964,0.00004115358,0.0001563828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001502236,0.0003230335,0.9620378,0.000446418,0.000402844,0.0005826151,0.0001094206,0.000002985415,0.00003206959,0.0008779684,0.02664843,0.008386199],"study_design_scores_gemma":[0.0008479183,0.00007734056,0.9934059,0.0001157672,0.0006343595,0.000003900644,0.00001484236,0.0002353616,0.0003536957,0.0001785744,0.004083544,0.00004884324],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758559,0.02257723,5.886764e-7,0.0009058267,0.00006647388,0.0001876866,0.0001937784,0.00004250142,0.0001699749],"genre_scores_gemma":[0.9924275,0.006857086,0.00003539286,0.0001574303,0.0001011221,0.00002008764,0.00007498607,0.000008975919,0.0003174107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03136806,"threshold_uncertainty_score":0.2169262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007374462965001364,"score_gpt":0.2624234556963297,"score_spread":0.2550489927313283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}