{"id":"W4365133704","doi":"10.1038/s41586-023-05806-1","title":"Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; McGill University; University of Calgary; University of Saskatchewan; Université Laval; Université de Montréal; Providence Health Care","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Ludwig Center at Harvard; National Institutes of Health; U.S. Department of Health and Human Services; Boston Scientific Corporation; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; Regeneron Pharmaceuticals; Leukemia and Lymphoma Society; Genentech; AstraZeneca","keywords":"Haematopoiesis; Gene knockdown; Biology; Stem cell; Mutation; Genetics; Allele; Gene; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002146031,0.0002652017,0.0001800292,0.0007422938,0.0003757465,0.0009193434,0.0003187642,0.0003990664,0.003332191],"category_scores_gemma":[0.0003886188,0.0002045555,0.000240602,0.0003171131,0.0003340601,0.0002540006,0.0003981977,0.001142895,0.00106485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009014339,"about_ca_system_score_gemma":0.0005129618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001471025,"about_ca_topic_score_gemma":0.003751555,"domain_scores_codex":[0.9995705,0.00005614048,0.00002725441,0.00005830987,0.0001592092,0.000128496],"domain_scores_gemma":[0.9997229,0.00005060375,0.00006977672,0.00003981236,0.00003684901,0.00008011186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235599,0.00004194851,0.001849034,0.00002821532,0.000008627991,0.0001774977,0.00002360594,0.0001612452,0.9921722,0.0007527074,0.0005418341,0.004119457],"study_design_scores_gemma":[0.00003203649,0.0001546046,0.01699299,0.00001137979,0.00002163466,0.001203445,0.00009469178,0.002719675,0.9685826,0.0003262313,0.009852828,0.000008020963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883136,0.002010768,0.002806301,0.0004256082,0.0000813135,0.00003391824,0.0007534508,0.0003051213,0.005270037],"genre_scores_gemma":[0.9966469,0.0003000093,0.0006957865,0.00006942703,0.00001142881,0.00001849168,0.0004455886,0.00003576624,0.001776567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003332191,"threshold_uncertainty_score":0.01114732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026636010115302,"score_gpt":0.3052177204833413,"score_spread":0.2849513603821883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}