{"id":"W4365135462","doi":"10.1083/jcb.202206061","title":"SIR telomere silencing depends on nuclear envelope lipids and modulates sensitivity to a lysolipid","year":2023,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Biology; Telomere; Gene silencing; Envelope (radar); Cell biology; Sensitivity (control systems); Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004559175,0.0001026733,0.0001454128,0.00007537018,0.00009540587,0.000009662294,0.00009618427,0.0001179089,0.00001475264],"category_scores_gemma":[0.00007975735,0.00006561355,0.00005132618,0.0001018128,0.00005324157,0.000002985661,0.0001032838,0.0001430147,0.0000322929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008948761,"about_ca_system_score_gemma":0.00002080463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008959783,"about_ca_topic_score_gemma":0.000007538623,"domain_scores_codex":[0.9993388,0.0001510893,0.0001609347,0.0001199083,0.0000585679,0.0001707211],"domain_scores_gemma":[0.9995633,0.00005341886,0.0001027616,0.0001480393,0.00006348379,0.00006893812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002724119,0.000007752418,0.0001943456,0.000005100927,0.00002873333,0.000004206431,0.0001711006,0.0002954389,0.9897,0.00003018392,0.001047724,0.00824296],"study_design_scores_gemma":[0.0006616212,0.002801076,0.01769908,0.00002277804,0.00005958503,0.0003187488,0.000554874,0.0002931646,0.919166,0.0003423755,0.0578313,0.0002494254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982512,0.00008171978,0.00005945924,0.0004317658,0.0003307468,0.00005050908,0.000004243066,0.000007511997,0.000782857],"genre_scores_gemma":[0.9981752,0.0003215626,0.0001624223,0.0006911398,0.0005094396,2.712682e-7,0.00000331169,0.00001540881,0.0001212666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07053407,"threshold_uncertainty_score":0.2675643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007383751579641787,"score_gpt":0.2214281798569018,"score_spread":0.21404442827726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}