{"id":"W4365135972","doi":"10.1080/07853890.2023.2198255","title":"Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort","year":2023,"lang":"en","type":"article","venue":"Annals of Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Medical Research Council; Barwon Health Foundation; Medical Research Future Fund; University of Adelaide; University of New South Wales; Juvenile Diabetes Research Foundation Australia; Juvenile Diabetes Research Foundation United States of America; Ministerio de Economía y Competitividad; Mountain Equipment Co-operative; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Omics; Autoimmunity; Type 1 diabetes; Pregnancy; Cohort; Medicine; Cohort study; Autoantibody; Case-control study; Immunology; Diabetes mellitus; Bioinformatics; Internal medicine; Biology; Antibody; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04016668,0.002641044,0.003004013,0.002380418,0.002765,0.0018175,0.002829782,0.004390281,0.0756983],"category_scores_gemma":[0.05543504,0.002362152,0.002399299,0.002146898,0.001444014,0.001450951,0.002039424,0.003812827,0.01706013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002084828,"about_ca_system_score_gemma":0.01076296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003777884,"about_ca_topic_score_gemma":0.006142707,"domain_scores_codex":[0.9769454,0.01456435,0.003238524,0.002597492,0.00180881,0.0008455284],"domain_scores_gemma":[0.9641074,0.0102375,0.003141394,0.01074076,0.009976478,0.001796443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1142535,0.01181035,0.02474406,0.0382443,0.003541322,0.003693191,0.006804204,0.01117283,0.01516371,0.05912373,0.4575849,0.2538639],"study_design_scores_gemma":[0.09580815,0.02082845,0.03780968,0.01604586,0.001646189,0.00129502,0.001580484,0.01228165,0.005813553,0.03603569,0.7701154,0.0007398826],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.002803701,0.0002861079,0.03132752,0.0004925934,0.0009791951,0.9493787,0.01150751,0.0004107756,0.00281386],"genre_scores_gemma":[0.002000064,0.00007687241,0.01409912,0.0002618271,0.00006734557,0.9817872,0.0009325886,0.00002329526,0.0007517145],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0756983,"threshold_uncertainty_score":0.2532361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07942951185387107,"score_gpt":0.3666213588807734,"score_spread":0.2871918470269024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}