{"id":"W4365138327","doi":"10.1021/acs.jnatprod.3c00159","title":"Modulation of <i>in Vitro</i> SARS-CoV-2 Infection by <i>Stephania tetrandra</i> and Its Alkaloid Constituents","year":2023,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"H2020 Marie Skłodowska-Curie Actions; National Center for Complementary and Integrative Health; National Institutes of Health; University of Washington; National Institute of Allergy and Infectious Diseases; European Commission; Office of Dietary Supplements","keywords":"Alkaloid; In vitro; Traditional medicine; Menispermaceae; Pharmacognosy; Chemistry; Biology; Stereochemistry; Medicine; Biochemistry; Biological activity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004940901,0.000110735,0.0003402328,0.0003631376,0.0000309759,0.00001396817,0.00005419332,0.00006955594,0.000002149083],"category_scores_gemma":[0.000484009,0.00008555538,0.00005801259,0.0008130565,0.00005047129,0.0003238636,0.00003146206,0.0004547678,0.000007559886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004550223,"about_ca_system_score_gemma":0.00009668719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000290137,"about_ca_topic_score_gemma":0.000004213337,"domain_scores_codex":[0.9987119,0.00005142606,0.0004351334,0.0001573944,0.0004431697,0.0002010075],"domain_scores_gemma":[0.9991567,0.00004521778,0.0002000981,0.00009621402,0.0004503268,0.00005144066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004445477,0.00009055899,0.003411179,0.0002330272,0.00004250456,0.00005556645,0.00005494362,0.000005277957,0.9849837,0.000004878582,0.005390401,0.005283348],"study_design_scores_gemma":[0.00235044,0.0002520337,0.02428353,0.0001798227,0.0000310891,0.000353928,0.00001292935,0.0003850192,0.9693102,0.00003601583,0.002726038,0.00007897588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947951,0.002409229,0.000002807475,0.002045258,0.0003514543,0.0002543144,0.000008449866,0.00001332384,0.0001199936],"genre_scores_gemma":[0.9982847,0.0009770425,0.00008967658,0.0001128238,0.0002041038,0.000001191437,0.00001817862,0.00001244966,0.0002998192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02087235,"threshold_uncertainty_score":0.3488847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828587639319617,"score_gpt":0.3175863679424756,"score_spread":0.2893004915492794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}