{"id":"W4365138327","doi":"10.1021/acs.jnatprod.3c00159","title":"Modulation of <i>in Vitro</i> SARS-CoV-2 Infection by <i>Stephania tetrandra</i> and Its Alkaloid Constituents","year":2023,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"H2020 Marie Skłodowska-Curie Actions; National Center for Complementary and Integrative Health; National Institutes of Health; University of Washington; National Institute of Allergy and Infectious Diseases; European Commission; Office of Dietary Supplements","keywords":"Alkaloid; In vitro; Traditional medicine; Menispermaceae; Pharmacognosy; Chemistry; Biology; Stereochemistry; Medicine; Biochemistry; Biological activity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006811298,0.0002133848,0.0001912337,0.0001679463,0.00009377005,0.0002467849,0.0001796922,0.0001725918,0.0008045922],"category_scores_gemma":[0.00005780453,0.00009401653,0.0002642396,0.0001237049,0.00009785275,0.0002076202,0.0001275007,0.0002906947,0.0002380975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780802,"about_ca_system_score_gemma":0.0001322118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267671,"about_ca_topic_score_gemma":0.0008616589,"domain_scores_codex":[0.9999563,0.000005355133,0.000004571232,0.00001145458,0.00001362473,0.000008811029],"domain_scores_gemma":[0.999961,0.000007553684,0.00001440924,0.000005170828,0.000006442243,0.000005446103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004554671,0.000008722254,0.0000958067,0.00002608921,0.000003584621,0.00001293631,0.000002542095,0.00003420523,0.9989636,0.00001943252,0.00001300041,0.0007745522],"study_design_scores_gemma":[0.000006523964,0.0002407308,0.003422281,0.000003787263,0.00001961647,0.0001012818,0.00001424247,0.0006281357,0.9942458,0.00002501807,0.001288697,0.000003881589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923571,0.001779673,0.003064336,0.00008376702,0.00001564251,0.00004151631,0.0007396003,0.0001128036,0.001805583],"genre_scores_gemma":[0.9905067,0.001460137,0.005289421,0.0000805488,0.000007766286,0.00003196972,0.001064992,0.00002324773,0.00153515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008045922,"threshold_uncertainty_score":0.002691686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828587639319617,"score_gpt":0.3175863679424756,"score_spread":0.2893004915492794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}