{"id":"W4365141405","doi":"10.1093/ofid/ofad195","title":"Principles and Terminology for Host–Microbiome–Drug Interactions","year":2023,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Calgary; University Health Network","funders":"","keywords":"Microbiome; Drug; Medicine; Terminology; Computational biology; Gut microbiome; Function (biology); Psychological intervention; Bioinformatics; Pharmacology; Biology; Evolutionary biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007112675,0.0001298408,0.0001463995,0.00008815401,0.0003144453,0.00009674096,0.0001757882,0.00004630282,0.00002964485],"category_scores_gemma":[0.00006586799,0.00012573,0.00007069887,0.0001011867,0.00007658768,0.00001221409,0.0004304699,0.00004664814,0.00004285731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001687385,"about_ca_system_score_gemma":0.00010073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009544615,"about_ca_topic_score_gemma":0.0007763857,"domain_scores_codex":[0.9991335,0.00002997797,0.0001608281,0.0003354689,0.00002466725,0.0003155086],"domain_scores_gemma":[0.9995153,0.00002915518,0.00007278397,0.0002236011,0.00005257067,0.0001065852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002360651,0.0003574998,0.2382044,0.0001882638,0.0002188724,0.000007617526,0.0001153614,0.00001835814,0.6035408,0.003937912,0.1468069,0.006367883],"study_design_scores_gemma":[0.001694896,0.0003956214,0.1493813,0.00003831772,0.00006997772,0.0001071148,0.0002650657,0.00004524222,0.01648586,0.0007890967,0.8303333,0.0003942044],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938466,0.0002754663,0.00009279657,0.001781864,0.0003556737,0.0007872844,0.0004359732,0.00006290987,0.002361448],"genre_scores_gemma":[0.9916114,0.0002603611,0.00007615166,0.0008238599,0.00008554873,0.0002073445,0.0006479971,0.00002661925,0.006260719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6835265,"threshold_uncertainty_score":0.5127121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01945278357550456,"score_gpt":0.3182314664010336,"score_spread":0.2987786828255291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}