{"id":"W4365143204","doi":"10.1016/j.ebiom.2023.104557","title":"Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection","year":2023,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Institut Curie; Université de Bordeaux; Agence Nationale de la Recherche; Styrelsen för Internationellt Utvecklingssamarbete; Wellcome Trust; Sidaction; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale","keywords":"Stimulator of interferon genes; Cytotoxic T cell; Priming (agriculture); CD8; Immune system; Biology; Immunology; T cell; Antigen; Context (archaeology); HIV Antigens; Virus; In vitro; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007808993,0.0005535265,0.0003922296,0.0002747631,0.0003172471,0.0005965056,0.0002455333,0.0005800049,0.003248794],"category_scores_gemma":[0.0005883062,0.0001576006,0.0003131677,0.00009565287,0.0004146797,0.0002563291,0.0002919348,0.0007233205,0.0007988547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006422042,"about_ca_system_score_gemma":0.0004325224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001629496,"about_ca_topic_score_gemma":0.0002238968,"domain_scores_codex":[0.9996319,0.0001203775,0.00003487505,0.00005671652,0.00004642848,0.0001095664],"domain_scores_gemma":[0.9995155,0.0001256476,0.00008242845,0.00007167732,0.0000742839,0.0001304767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001025464,0.0001213097,0.00137399,0.0002446779,0.000009249648,0.0002707594,0.00007058736,0.000138276,0.9825007,0.0006288303,0.0003667043,0.01324943],"study_design_scores_gemma":[0.0003663111,0.00214118,0.04645857,0.0003434705,0.0001074436,0.002558043,0.0004341427,0.003279068,0.9247568,0.002676856,0.01684996,0.00002815371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559154,0.02034034,0.01118115,0.001013809,0.0003604168,0.0001719803,0.000390516,0.0002144403,0.01041191],"genre_scores_gemma":[0.9916433,0.002040025,0.003754387,0.0002156109,0.0001358941,0.0001083948,0.0001384653,0.00003147907,0.001932455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003248794,"threshold_uncertainty_score":0.01086825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735596792862176,"score_gpt":0.24097850223821,"score_spread":0.2236225343095882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}