{"id":"W4365143649","doi":"10.1038/s41586-023-05937-5","title":"Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Cancer Prevention and Research Institute of Texas; Arctic Goose Joint Venture; Medical Research Council; Ministry of Food and Drug Safety; Stand Up To Cancer; University of California, San Diego; Ministry of Science and ICT, South Korea; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute for Health and Care Research; National Cancer Institute; National Institutes of Health; Cancer Research UK","keywords":"Medicine; Dysplasia; Cancer; Stage (stratigraphy); Internal medicine; Biopsy; Oncology; Gastroenterology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213103,0.0000589749,0.00006187704,0.00002929753,0.00002261151,0.000007474149,0.0001439809,0.0003569055,0.000006657389],"category_scores_gemma":[0.0000417868,0.00004571568,0.00004049658,0.0001600481,0.00002191568,0.000001876198,0.00001442531,0.0002716602,0.000003475144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000977234,"about_ca_system_score_gemma":0.00005364868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003167902,"about_ca_topic_score_gemma":0.0003150372,"domain_scores_codex":[0.9995698,0.00001791266,0.0001063376,0.0001004896,0.00009446943,0.0001109448],"domain_scores_gemma":[0.9997599,0.00001875147,0.00002897375,0.000150846,0.00002691762,0.00001464864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005314111,0.0002865377,0.02590007,0.00031655,0.0001266141,0.00009626417,0.006687829,0.004856,0.7830241,0.01037105,0.1165827,0.0512209],"study_design_scores_gemma":[0.00257113,0.0005742981,0.2649319,0.00005847594,0.0000468901,0.00004899539,0.001285148,0.0007280833,0.6171902,0.001456788,0.1106228,0.000485295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929006,0.005070543,0.00002802792,0.0007561903,0.0002224966,0.0001370166,0.00008270969,0.000005516462,0.000796874],"genre_scores_gemma":[0.9985854,0.0004558099,0.00002199791,0.0005578422,0.0001653954,0.00001554219,0.0001547355,0.000006694428,0.00003657986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2390319,"threshold_uncertainty_score":0.2752782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006184134101108579,"score_gpt":0.251221290023611,"score_spread":0.2450371559225024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}