{"id":"W4365143649","doi":"10.1038/s41586-023-05937-5","title":"Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Cancer Prevention and Research Institute of Texas; Arctic Goose Joint Venture; Medical Research Council; Ministry of Food and Drug Safety; Stand Up To Cancer; University of California, San Diego; Ministry of Science and ICT, South Korea; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute for Health and Care Research; National Cancer Institute; National Institutes of Health; Cancer Research UK","keywords":"Medicine; Dysplasia; Cancer; Stage (stratigraphy); Internal medicine; Biopsy; Oncology; Gastroenterology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002952162,0.000182805,0.0001968919,0.001682524,0.0001926752,0.0005135155,0.0001544967,0.0002973605,0.001176137],"category_scores_gemma":[0.0008520461,0.0001579228,0.0002065542,0.0009172733,0.0002994507,0.0001876759,0.0002649791,0.0002447571,0.0001449355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488277,"about_ca_system_score_gemma":0.00009863717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002536645,"about_ca_topic_score_gemma":0.004336965,"domain_scores_codex":[0.9996889,0.00006061579,0.00002610068,0.0001020923,0.00008286714,0.0000395232],"domain_scores_gemma":[0.9994748,0.0001132171,0.0002267567,0.00005932521,0.00006259332,0.0000634053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006201614,0.00002930624,0.8469812,0.000173738,0.0002343622,0.0007454961,0.0003551065,0.0002748194,0.1296859,0.0002464396,0.0001561458,0.02049737],"study_design_scores_gemma":[0.000003540158,0.00005669863,0.993555,0.00001241144,0.00003428882,0.0008414433,0.00006306962,0.0001852742,0.004377991,0.00006377103,0.0008034057,0.000003188816],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994409,0.003746866,0.0004449749,0.00004678018,0.000009428454,0.000005887215,0.000451988,0.00001365459,0.0008712995],"genre_scores_gemma":[0.9986998,0.0003974644,0.0002556937,0.00002243322,0.000005421249,0.000003301933,0.0003776286,0.000003399075,0.0002347523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002536645,"threshold_uncertainty_score":0.005043805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006184134101108579,"score_gpt":0.251221290023611,"score_spread":0.2450371559225024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}