{"id":"W4365143915","doi":"10.1038/s41591-023-02232-8","title":"Body composition and lung cancer-associated cachexia in TRACERx","year":2023,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Nutrition and Health in Aging","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Memorial University of Newfoundland","funders":"FP7 People: Marie-Curie Actions; Medical Research Council; Pfizer UK; Genentech; Gdański Uniwersytet Medyczny; Novo Nordisk Fonden; University College London Hospitals NHS Foundation Trust; NIHR Cambridge Biomedical Research Centre; Peter MacCallum Cancer Centre; Stand Up To Cancer; Novo Nordisk; Deutsche Forschungsgemeinschaft; University of Glasgow; National Institutes of Health; Rosetrees Trust; University College London; Wellcome Trust; Cancer Research UK; Foulkes Foundation; Francis Crick Institute; Institut for Klinisk Medicin, Aarhus Universitet; International Association for the Study of Lung Cancer; BeiGene; National Institute for Health and Care Research; Aarhus Universitetshospital; National Cancer Institute; Gilead Sciences; Brigham and Women's Hospital; European Commission; Aarhus Universitet; Breast Cancer Research Foundation; Sanofi; Massachusetts General Hospital; GlaxoSmithKline; Bristol-Myers Squibb; Ono Pharmaceutical; Lundbeckfonden; Eli Lilly and Company; AstraZeneca; Amgen; Pfizer","keywords":"Cancer cachexia; Cachexia; Lung cancer; Medicine; Composition (language); Cancer; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000461786,0.0001077807,0.0003288903,0.0003438126,0.00006825899,0.000003727268,0.00003319585,0.0002596734,0.0001416082],"category_scores_gemma":[0.0001401081,0.00008760169,0.00001927374,0.0007476604,0.00006271661,0.00003531983,0.00001343919,0.0008647524,0.000005253996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854742,"about_ca_system_score_gemma":0.00005323696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002028744,"about_ca_topic_score_gemma":0.0001296025,"domain_scores_codex":[0.9989669,0.00004427722,0.0002445466,0.0002032069,0.0002856385,0.0002554658],"domain_scores_gemma":[0.9995112,0.0001009615,0.0000584203,0.00009618781,0.00007597525,0.0001572575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000764363,0.0004534908,0.5754167,0.002896252,0.0001556474,0.001039744,0.0048672,0.000007464108,0.1597026,0.002119516,0.2411594,0.01141767],"study_design_scores_gemma":[0.00884279,0.0002087201,0.9725612,0.003080986,0.0001229133,0.00005234895,0.0003306748,0.005327663,0.00121875,0.0002420456,0.007867479,0.0001443889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902881,0.009504794,0.000004557055,0.08471512,0.0005148779,0.0004028136,0.00001022354,0.0001749841,0.001791604],"genre_scores_gemma":[0.9910775,0.001827953,0.0000422216,0.005828383,0.0004241428,0.00002963718,0.0001930487,0.00001654922,0.0005605908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3971446,"threshold_uncertainty_score":0.3756967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01983808981171395,"score_gpt":0.3967702250189669,"score_spread":0.376932135207253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}