{"id":"W4365146522","doi":"10.1038/s41467-023-37573-y","title":"A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; National Eye Institute; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Aspergillus fumigatus; Caspofungin; Cryptococcus neoformans; Microbiology; Aspergillosis; Fungal keratitis; Biology; Amphotericin B; Candida albicans; Antifungal drug; Aspergillus; Voriconazole; Drug resistance; Echinocandin; Antifungal; Immunology; Fluconazole; Keratitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849831,0.0003171101,0.0001889203,0.0001854951,0.00009004147,0.000174024,0.0001663472,0.0001963479,0.001078982],"category_scores_gemma":[0.0001069656,0.00008212856,0.0001579852,0.00007594957,0.0001259112,0.000158934,0.0001567945,0.0003692704,0.0002378719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001106871,"about_ca_system_score_gemma":0.0001260837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001630816,"about_ca_topic_score_gemma":0.0003018573,"domain_scores_codex":[0.9999032,0.00003252317,0.000008069789,0.00001219847,0.00002237554,0.00002151277],"domain_scores_gemma":[0.9999486,0.00001017614,0.00001521528,0.000004680247,0.00000500373,0.00001625278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000403481,0.0001279275,0.0001841287,0.00007782964,0.000008932812,0.0000857359,0.000008715255,0.0001173336,0.9921904,0.0000453563,0.0001623657,0.00658777],"study_design_scores_gemma":[0.0002389329,0.005965584,0.00646943,0.00001988384,0.00005919874,0.001276598,0.00002096558,0.0008311638,0.9772304,0.0000487821,0.007828384,0.00001074552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881756,0.006980284,0.001161363,0.0002367435,0.00008849926,0.0000545894,0.0001551962,0.000093854,0.003053945],"genre_scores_gemma":[0.9947721,0.002254112,0.001666556,0.0000998114,0.00004313004,0.00001935082,0.000163405,0.000005794487,0.0009757532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078982,"threshold_uncertainty_score":0.003609598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0322807994164233,"score_gpt":0.32926039849122,"score_spread":0.2969795990747967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}