{"id":"W4365148022","doi":"10.3390/molecules28083385","title":"Aurora B Inhibitors as Cancer Therapeutics","year":2023,"lang":"en","type":"review","venue":"Molecules","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thunder Bay Regional Research Institute; Lakehead University","funders":"Natural Sciences and Engineering Research Council of Canada; Lakehead University","keywords":"Aurora B kinase; Aurora kinase; Aurora inhibitor; Mitosis; Kinase; Cancer research; Spindle checkpoint; Drug target; Serine; Cancer; Biology; Spindle apparatus; Cell biology; Genetics; Cell division; Cell cycle; Phosphorylation; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009413642,0.000472536,0.000693402,0.0001053739,0.00007667816,0.00004997837,0.0004226425,0.0006259834,0.00002248361],"category_scores_gemma":[0.00002461132,0.000406615,0.000540582,0.0002165566,0.00007476479,0.000001390562,0.0002635505,0.0002452951,0.000302137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003812131,"about_ca_system_score_gemma":0.0004024916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005710051,"about_ca_topic_score_gemma":0.00007302759,"domain_scores_codex":[0.9983662,0.0001002565,0.0004094073,0.0005945993,0.0001533889,0.0003761397],"domain_scores_gemma":[0.9990578,0.00001336894,0.0002117285,0.0005724662,0.00005773665,0.00008687201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006812322,0.00004894375,0.000003018694,0.003950374,0.00079826,0.00003112823,0.00002055007,0.000004056909,0.003139351,0.0001341517,0.01029776,0.9815656],"study_design_scores_gemma":[0.00008937839,0.00006731588,4.693003e-7,0.001718379,0.0004693212,0.00001828873,0.00000906115,0.000002634983,0.001195541,0.000026804,0.995945,0.0004578276],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001710682,0.9977999,0.00007085971,0.00003164016,0.0005944614,0.0004820822,0.0001573752,0.00005262534,0.0006399371],"genre_scores_gemma":[0.000006240283,0.9917489,0.00009006465,0.000343467,0.0006023475,0.000235388,0.000731071,0.0001904996,0.006051999],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9856472,"threshold_uncertainty_score":0.9998386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141382840329721,"score_gpt":0.3482281275287385,"score_spread":0.3068142991254413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}