{"id":"W4365149034","doi":"10.1016/j.jcyt.2023.03.008","title":"Independent human mesenchymal stromal cell–derived extracellular vesicle preparations differentially attenuate symptoms in an advanced murine graft-versus-host disease model","year":2023,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020; European Regional Development Fund; Horizon 2020 Framework Programme; European Cooperation in Science and Technology; European Commission; Stem Cell Network","keywords":"Mesenchymal stem cell; In vivo; Stromal cell; Immune system; In vitro; Graft-versus-host disease; Bone marrow; Immunology; Clinical significance; Medicine; Inflammation; Disease; Cancer research; Chemistry; Biology; Pathology; Biochemistry; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003995927,0.0006031443,0.0003663983,0.0003668423,0.0001301642,0.0004034906,0.0001749277,0.0004664391,0.0008379598],"category_scores_gemma":[0.000242095,0.00008869779,0.0003861496,0.000186813,0.0002642238,0.000264218,0.0002740705,0.0006376012,0.0003057912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001499259,"about_ca_system_score_gemma":0.0001797832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009335668,"about_ca_topic_score_gemma":0.0001514037,"domain_scores_codex":[0.9996216,0.00008593951,0.00005894207,0.00008115309,0.00009882478,0.00005353814],"domain_scores_gemma":[0.9998277,0.000043393,0.00005229739,0.00002566212,0.00002434849,0.0000265438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004825302,0.0001506678,0.0002617081,0.00008601403,0.00002053339,0.0000404469,0.00001841678,0.0001189845,0.9960576,0.00009583047,0.0000365606,0.002630708],"study_design_scores_gemma":[0.00002381589,0.001354462,0.001630002,0.00001132313,0.00006156123,0.000136559,0.00001615534,0.0003774485,0.9946616,0.00003442569,0.001688355,0.000004278962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898545,0.002198478,0.005972572,0.00006301745,0.00007362703,0.0001221259,0.0005200572,0.0000584835,0.001137199],"genre_scores_gemma":[0.9901147,0.001197023,0.005566533,0.00007954898,0.00002952843,0.0001811443,0.001249937,0.00004197425,0.001539542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008379598,"threshold_uncertainty_score":0.002803206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872668710906369,"score_gpt":0.2971841944442185,"score_spread":0.2784575073351548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}