{"id":"W4365151239","doi":"10.1016/j.bbamcr.2023.119476","title":"Ligand-dependent intracellular trafficking of the G protein-coupled P2Y6 receptor","year":2023,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Crohn's and Colitis Canada","keywords":"Internalization; Endosome; Cell biology; Endocytosis; Receptor; G protein-coupled receptor; Agonist; Biology; Clathrin; Intracellular; Chemistry; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556012,0.0001431845,0.0001755341,0.0001329676,0.0002561502,0.0005079596,0.0002125148,0.0003009984,0.001695647],"category_scores_gemma":[0.0002041348,0.0001017859,0.0002391955,0.0001366904,0.0001754474,0.0004836356,0.0002016255,0.000509956,0.0008352689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003446515,"about_ca_system_score_gemma":0.0001942189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005215644,"about_ca_topic_score_gemma":0.0007036294,"domain_scores_codex":[0.999876,0.00003042588,0.000008113981,0.00001947174,0.00003221354,0.00003382922],"domain_scores_gemma":[0.9999511,0.0000166954,0.000008045501,0.000007820562,0.000005876208,0.00001053752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002648507,0.00001335302,0.00008222975,0.00003680767,0.000003358977,0.0001114556,0.00003304314,0.0001000062,0.9963742,0.001075683,0.00009220755,0.001812833],"study_design_scores_gemma":[0.0000636464,0.000182686,0.007498395,0.00001254767,0.00001414376,0.0009911314,0.0001091981,0.004918748,0.979386,0.0004934287,0.006317005,0.00001297059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907497,0.001779224,0.00313471,0.0003607144,0.00002607385,0.00001792834,0.0004283243,0.00004643992,0.003456882],"genre_scores_gemma":[0.9918447,0.001559989,0.00187067,0.00009019383,0.00001957137,0.00001923261,0.0006054378,0.00003152278,0.00395852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695647,"threshold_uncertainty_score":0.005672455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02616171759046045,"score_gpt":0.2987853046254814,"score_spread":0.272623587035021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}