{"id":"W4365446409","doi":"10.1016/j.cell.2023.02.040","title":"Selpercatinib: First approved selective RET inhibitor","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Fusion protein; Cell biology; Small molecule; Cancer research; Kinase; Point mutation; Mutant; Biochemistry; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002524379,0.0004069781,0.000628059,0.0004811471,0.0002986829,0.0008057922,0.0003279871,0.000572698,0.005566609],"category_scores_gemma":[0.0003924654,0.0001088369,0.0004824449,0.0003847519,0.0001980403,0.0004819422,0.0002764487,0.001200537,0.00208964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001010132,"about_ca_system_score_gemma":0.0009553545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026503,"about_ca_topic_score_gemma":0.004861045,"domain_scores_codex":[0.9998381,0.00002191707,0.00001717641,0.00002850897,0.00005190376,0.0000424746],"domain_scores_gemma":[0.9998789,0.00002046167,0.00002801538,0.00000546843,0.00003461105,0.00003260343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004663679,0.0005289226,0.008160776,0.001942165,0.0005983498,0.001344331,0.0000736225,0.001263291,0.0306975,0.003977204,0.1442056,0.8025445],"study_design_scores_gemma":[0.003709029,0.006190096,0.02465433,0.0007820594,0.001231368,0.01035469,0.0001358457,0.002291455,0.04368639,0.002989977,0.9038702,0.0001044665],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3475147,0.4218635,0.004183482,0.03812999,0.005850764,0.0006556992,0.01814944,0.001868708,0.1617836],"genre_scores_gemma":[0.7845072,0.1074689,0.003845975,0.01281893,0.001128571,0.0003343744,0.01207794,0.0001399725,0.07767811],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005566609,"threshold_uncertainty_score":0.0186221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456587240450001,"score_gpt":0.2955862916170882,"score_spread":0.2810204192125882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}