{"id":"W4365446409","doi":"10.1016/j.cell.2023.02.040","title":"Selpercatinib: First approved selective RET inhibitor","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Fusion protein; Cell biology; Small molecule; Cancer research; Kinase; Point mutation; Mutant; Biochemistry; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003531983,0.00007037743,0.0001012565,0.0000512168,0.00007946252,0.000008551462,0.00002608371,0.00003995223,0.00008824313],"category_scores_gemma":[0.00002223995,0.00005671705,0.00004098672,0.0002988373,0.00001806728,0.00002883312,0.0000142002,0.00006691878,0.0007194536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009041851,"about_ca_system_score_gemma":0.00009708297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004272983,"about_ca_topic_score_gemma":0.00001845162,"domain_scores_codex":[0.9995167,0.000006971342,0.00008352558,0.0001592776,0.00008965434,0.000143839],"domain_scores_gemma":[0.9996757,0.00003631468,0.00002267797,0.0001390962,0.00005416191,0.00007206014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001574444,0.0006963052,0.02222968,0.0004220502,0.0002921893,0.0001491762,0.01482747,0.00005089449,0.0319397,0.0001623448,0.9248744,0.004198339],"study_design_scores_gemma":[0.008168537,0.001024818,0.1115133,0.0001769013,0.00066498,0.00002909918,0.002798365,0.001254736,0.1659695,0.0004540913,0.7075014,0.0004443217],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8042216,0.0001830847,0.00003916279,0.003825512,0.0004404444,0.0007496194,0.0000328572,0.0004375435,0.1900702],"genre_scores_gemma":[0.9669548,0.00003742226,0.0003288993,0.0002635943,0.0001918057,0.00008168934,0.0001189475,0.00001987451,0.03200293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2173731,"threshold_uncertainty_score":0.924736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456587240450001,"score_gpt":0.2955862916170882,"score_spread":0.2810204192125882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}