{"id":"W4365452464","doi":"10.1016/j.critrevonc.2023.103987","title":"KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics","year":2023,"lang":"en","type":"review","venue":"Critical Reviews in Oncology/Hematology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"KRAS; Colorectal cancer; Microsatellite instability; Targeted therapy; ARID1A; Medicine; Mutation; Cancer research; Oncology; Cancer; Internal medicine; Bioinformatics; Biology; Gene; Genetics; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008701957,0.00070432,0.001694257,0.001703145,0.0001335911,0.001109234,0.0005534772,0.0006441572,0.002917141],"category_scores_gemma":[0.001433452,0.0002392102,0.0008426957,0.001673362,0.0003344919,0.0009481542,0.0005962006,0.001482463,0.0009665526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007015353,"about_ca_system_score_gemma":0.001710936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009141898,"about_ca_topic_score_gemma":0.003116143,"domain_scores_codex":[0.9997693,0.00004836167,0.00004401403,0.00004081197,0.00007115238,0.00002646205],"domain_scores_gemma":[0.9994412,0.0002882658,0.0001101893,0.0000121038,0.0001130223,0.00003515347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002398074,0.00004170153,0.0003129005,0.02277324,0.0003278459,0.00006201562,0.00002444328,0.0002302001,0.0008648048,0.001703655,0.03404969,0.9393697],"study_design_scores_gemma":[0.0001904467,0.0003646347,0.002473465,0.02044715,0.001694016,0.0007298281,0.00007174123,0.0001884726,0.0005495769,0.002741116,0.9705071,0.00004253544],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007885911,0.9990751,0.00005528882,0.0003391043,0.0001443253,0.000003519571,0.00003002666,0.000004644834,0.0002691669],"genre_scores_gemma":[0.000710934,0.9982355,0.0001614755,0.0004545398,0.0001732812,0.000006511863,0.00005061271,0.000001125973,0.0002060053],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002917141,"threshold_uncertainty_score":0.00975883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1545728395195912,"score_gpt":0.5159820336971392,"score_spread":0.361409194177548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}