{"id":"W4365454263","doi":"10.3390/cancers15082258","title":"Insights into the Molecular Mechanisms Mediating Extravasation in Brain Metastasis of Breast Cancer, Melanoma, and Lung Cancer","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Advanced Technology Research Council; Terry Fox Foundation; University of Sharjah","keywords":"Extravasation; Metastasis; Brain metastasis; Blood–brain barrier; Cancer; Medicine; Melanoma; Circulating tumor cell; Breast cancer; Lung cancer; Pathology; Cancer research; Internal medicine; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002342729,0.0005791608,0.0009140731,0.001647466,0.0002364925,0.0006492829,0.0004658576,0.0006165953,0.002144153],"category_scores_gemma":[0.0003430742,0.0001832448,0.0004791737,0.001394163,0.0002542533,0.0007872952,0.000389452,0.001154576,0.0009578983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004726223,"about_ca_system_score_gemma":0.0007328916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001066626,"about_ca_topic_score_gemma":0.002077288,"domain_scores_codex":[0.9999081,0.00001395882,0.00001363774,0.0000154512,0.00003653145,0.00001248617],"domain_scores_gemma":[0.9999014,0.00003906762,0.00001567081,0.000002598887,0.00003129308,0.000009977802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001026006,0.0001045946,0.0004067706,0.031173,0.0001401526,0.0004879395,0.0001285838,0.0005549682,0.006556145,0.005714952,0.0271233,0.9275069],"study_design_scores_gemma":[0.00001930378,0.0001623712,0.002135355,0.004464827,0.0001970038,0.002574197,0.00009178447,0.0001601344,0.001259167,0.002423377,0.9864889,0.00002363647],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001906183,0.998655,0.0000875932,0.0001438975,0.0001066252,0.000003559178,0.00001704451,0.000004353687,0.000791333],"genre_scores_gemma":[0.0008137441,0.99854,0.0001039088,0.00008862938,0.00006396118,0.000004437978,0.00002348693,5.967417e-7,0.0003612438],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002144153,"threshold_uncertainty_score":0.007172942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03389607265344999,"score_gpt":0.3529158762161819,"score_spread":0.3190198035627319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}