{"id":"W4365456978","doi":"10.1021/acsinfecdis.2c00416","title":"Sphingosine Kinases Promote Ebola Virus Infection and Can Be Targeted to Inhibit Filoviruses, Coronaviruses, and Arenaviruses Using Late Endocytic Trafficking to Enter Cells","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada; Institute of Infection and Immunity; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Public Health Agency of Canada; Government of Canada; Public Health Agency; University of Ottawa","keywords":"Endosome; Endocytic cycle; Viral entry; Ebola virus; Endocytosis; Biology; Cell biology; Lipid bilayer fusion; Viral envelope; Sphingosine; Virology; Sphingosine kinase; Viral replication; Sphingosine kinase 1; Virus; Intracellular; Sphingosine-1-phosphate; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002029749,0.0004543976,0.0005519783,0.001009001,0.0005939903,0.0002992825,0.00007353836,0.0001387018,0.00009787778],"category_scores_gemma":[0.0004496286,0.0004305234,0.0001218538,0.001474128,0.0001535292,0.0003051155,0.0003241799,0.0003326838,0.00007818964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003244671,"about_ca_system_score_gemma":0.0001913711,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007836984,"about_ca_topic_score_gemma":0.003052105,"domain_scores_codex":[0.9974347,0.0001228095,0.0004520801,0.0007682059,0.0004519149,0.0007702722],"domain_scores_gemma":[0.9982884,0.0001843099,0.0001021904,0.0003548859,0.0002135461,0.0008566977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005114782,0.0006667829,0.2479592,0.0005160398,0.0003051289,0.0003891206,0.0009915631,0.002236623,0.7274297,0.00002854833,0.002088156,0.01687766],"study_design_scores_gemma":[0.006018841,0.004086704,0.4490196,0.001513801,0.00117673,0.0005045636,0.0002581017,0.002212826,0.5076185,0.0001780386,0.02560132,0.001810992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963185,0.0003137381,0.000097358,0.0002715138,0.0003120426,0.001483844,0.0003823954,0.0007359672,0.00008468087],"genre_scores_gemma":[0.9966866,0.0006864287,0.00005749813,0.001749247,0.000276884,0.0001460745,0.00008848664,0.0001064284,0.0002023123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2198112,"threshold_uncertainty_score":0.9998146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04038945815803807,"score_gpt":0.3279477983010261,"score_spread":0.287558340142988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}