{"id":"W4365456978","doi":"10.1021/acsinfecdis.2c00416","title":"Sphingosine Kinases Promote Ebola Virus Infection and Can Be Targeted to Inhibit Filoviruses, Coronaviruses, and Arenaviruses Using Late Endocytic Trafficking to Enter Cells","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada; Institute of Infection and Immunity; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Public Health Agency of Canada; Government of Canada; Public Health Agency; University of Ottawa","keywords":"Endosome; Endocytic cycle; Viral entry; Ebola virus; Endocytosis; Biology; Cell biology; Lipid bilayer fusion; Viral envelope; Sphingosine; Virology; Sphingosine kinase; Viral replication; Sphingosine kinase 1; Virus; Intracellular; Sphingosine-1-phosphate; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001143931,0.0003967401,0.0002548778,0.0002203119,0.0001551166,0.0002520682,0.0001375244,0.0002235303,0.001328526],"category_scores_gemma":[0.0000858232,0.0001322587,0.000248362,0.0001217116,0.0001733607,0.0002252535,0.0001832689,0.0005530403,0.0002895965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000226567,"about_ca_system_score_gemma":0.0002566658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000545917,"about_ca_topic_score_gemma":0.001126282,"domain_scores_codex":[0.9999156,0.00001229285,0.000009453218,0.00001210113,0.00002110937,0.00002945771],"domain_scores_gemma":[0.9999502,0.000009756981,0.00001195747,0.000005470698,0.000006719524,0.00001594569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001536475,0.00004882337,0.00007705823,0.00004568463,0.000006356437,0.00002512869,0.00001089791,0.00008725339,0.9983134,0.0001365183,0.00004292447,0.001052341],"study_design_scores_gemma":[0.00002975083,0.0002492575,0.001194188,0.000005607116,0.00001403722,0.00007899436,0.00001026596,0.0005620319,0.9958313,0.00003890188,0.001983034,0.000002579511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899471,0.003681526,0.001929886,0.0001545638,0.0000491989,0.00005525213,0.0003192164,0.00009067541,0.003772546],"genre_scores_gemma":[0.9923688,0.00208409,0.00199779,0.00005713718,0.00001599262,0.00006227187,0.0004295215,0.00001214338,0.002972343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328526,"threshold_uncertainty_score":0.004444361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04038945815803807,"score_gpt":0.3279477983010261,"score_spread":0.287558340142988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}