{"id":"W4365457148","doi":"10.1016/s1474-4422(23)00077-7","title":"Safety and efficacy of rozanolixizumab in patients with generalised myasthenia gravis (MycarinG): a randomised, double-blind, placebo-controlled, adaptive phase 3 study","year":2023,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":260,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"UCB Pharma; National Institute of Neurological Disorders and Stroke","keywords":"Myasthenia gravis; Placebo; Medicine; Double blind; Phase (matter); Physical medicine and rehabilitation; Anesthesia; Physical therapy; Internal medicine; Alternative medicine; Physics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001685643,0.001508295,0.003229717,0.0003969394,0.000451224,0.001144044,0.0009067074,0.002655932,0.004261289],"category_scores_gemma":[0.001631888,0.0007337512,0.002338378,0.0003715809,0.001567402,0.001219781,0.0003496772,0.00316077,0.001086207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006780599,"about_ca_system_score_gemma":0.0007987787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008259655,"about_ca_topic_score_gemma":0.001435132,"domain_scores_codex":[0.9993469,0.0003340321,0.00003961971,0.0001035474,0.00005033808,0.0001254579],"domain_scores_gemma":[0.9990459,0.0003052517,0.0002064808,0.00009080605,0.00005352312,0.000297993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9757845,0.003823128,0.0006502854,0.0004645224,0.0006937471,0.00005609029,0.00006094916,0.0002068566,0.004408354,0.00006751208,0.0004165013,0.01336744],"study_design_scores_gemma":[0.9348607,0.06120643,0.002824223,0.00001898835,0.0002737954,0.00003361248,0.00001546523,0.0001719288,0.0002089011,0.00007756536,0.0002931726,0.00001514247],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902294,0.005074949,0.0004545039,0.000565258,0.0003071751,0.001365528,0.0005878801,0.00009315597,0.001322227],"genre_scores_gemma":[0.9920754,0.001971046,0.0008071536,0.001071909,0.0003307807,0.001496512,0.0006018974,0.00002251023,0.001622833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004261289,"threshold_uncertainty_score":0.0142554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03103543463197126,"score_gpt":0.2935092215555304,"score_spread":0.2624737869235592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}