{"id":"W4365458935","doi":"10.1088/1748-605x/acccc4","title":"A biopolymeric mesh enriched with PLGA microparticles loaded with AT101 for localized glioblastoma treatment","year":2023,"lang":"en","type":"article","venue":"Biomedical Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; BC Cancer Foundation; Deutsche Forschungsgemeinschaft","keywords":"PLGA; Glioblastoma; Adjuvant; Apoptosis; Drug delivery; Cytotoxic T cell; Materials science; Cancer research; Pharmacology; Biomedical engineering; Medicine; Nanotechnology; Chemistry; Oncology; Nanoparticle; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004743945,0.000219395,0.0001604768,0.0001995631,0.0001032106,0.0001746019,0.000107742,0.0002400745,0.0004610929],"category_scores_gemma":[0.00005163512,0.0001022581,0.0002225201,0.0001134947,0.0001078684,0.0001427555,0.000134378,0.0001960323,0.0001269326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115319,"about_ca_system_score_gemma":0.0001264906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006741992,"about_ca_topic_score_gemma":0.001183211,"domain_scores_codex":[0.9999616,0.000002986276,0.000003093937,0.00001023378,0.00001243897,0.000009619924],"domain_scores_gemma":[0.9999738,0.000004151623,0.000009929058,0.000002024644,0.00000303516,0.000007131133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003570036,0.0000118162,0.00004354621,0.00003565228,0.000003122007,0.00002734463,0.000004679569,0.0001221594,0.9977538,0.00003291708,0.00002167574,0.001907632],"study_design_scores_gemma":[0.00001166341,0.0004246748,0.001383017,0.00000758539,0.00002457216,0.0001145497,0.000008818537,0.001538181,0.9947981,0.00001669401,0.001664156,0.000007963906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98857,0.002493361,0.007388757,0.00008701406,0.00005734262,0.00004997821,0.0001363876,0.00009987387,0.001117167],"genre_scores_gemma":[0.9916829,0.001061901,0.005617063,0.00003912802,0.00001216366,0.00003451962,0.00008736576,0.00001817059,0.001446791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006741992,"threshold_uncertainty_score":0.001542509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130685421405451,"score_gpt":0.2571068411021571,"score_spread":0.244038298961612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}