{"id":"W4365479293","doi":"10.1182/bloodadvances.2023009781","title":"Activity of luspatercept and ESAs combination for treatment of anemia in lower-risk myelodysplastic syndromes","year":2023,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Daiichi Sankyo Europe; CTI Biopharma; Incyte; Sierra Oncology; Celgene; MorphoSys; Servier; Astellas Pharma; Syndax Pharmaceuticals; Gilead Sciences; Bristol-Myers Squibb; Agios Pharmaceuticals","keywords":"Myelodysplastic syndromes; Anemia; Medicine; Oncology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384488,0.000102462,0.0003595626,0.0002228887,0.00002572953,0.000003155915,0.00004269338,0.00005348589,0.00000991235],"category_scores_gemma":[0.0002006627,0.00008180792,0.00004460905,0.0003018867,0.0001047765,0.00009868145,0.00002367107,0.00004432133,0.000002368877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006940058,"about_ca_system_score_gemma":0.00008088706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008987415,"about_ca_topic_score_gemma":0.00007165552,"domain_scores_codex":[0.9992512,0.00003476764,0.0001664185,0.000194462,0.0001697095,0.000183371],"domain_scores_gemma":[0.9991751,0.0004633538,0.0001044108,0.0001425339,0.00006459891,0.00004997843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002879082,0.00285871,0.5631796,0.002997748,0.000306456,0.0001753899,0.001899419,0.0002630091,0.1382358,0.0002023423,0.0001237294,0.2868787],"study_design_scores_gemma":[0.01603032,0.008525939,0.7754686,0.0003202308,0.0003092347,0.00004233484,0.0004413626,0.003016755,0.1941721,0.0007276526,0.0007679282,0.0001775058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983576,0.0005611954,0.00005546078,0.0001810419,0.00005111879,0.0006145308,0.00005552979,0.00002421744,0.00009931321],"genre_scores_gemma":[0.9963136,0.002631179,0.0005466607,0.000002539539,0.00001821438,0.00007381175,0.00002227443,0.00001315148,0.0003786228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2867012,"threshold_uncertainty_score":0.333603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239236770013055,"score_gpt":0.3198697072487417,"score_spread":0.2974773395486112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}