{"id":"W4365483305","doi":"10.1093/ecco-jcc/jjad050","title":"Resolving Histological Inflammation in Ulcerative Colitis With Mirikizumab in the LUCENT Induction and Maintenance Trial Programmes","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"UCB Pharma; Samsung; Genentech; Norgine; Medac; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; Tillotts Pharma; Celltrion; Gilead Sciences; Pfizer; Ono Pharmaceutical; Eli Lilly and Company; Bristol-Myers Squibb; Biogen; GlaxoSmithKline","keywords":"Medicine; Ulcerative colitis; Internal medicine; Gastroenterology; Placebo; Tofacitinib; Inflammatory bowel disease; Disease; Pathology; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001782409,0.000594886,0.001418659,0.0002064101,0.0002275329,0.0006591257,0.0005932212,0.0005377592,0.002424836],"category_scores_gemma":[0.0009150103,0.0002092792,0.001238683,0.0002286337,0.0003923618,0.0005679555,0.0003047173,0.001235075,0.0002647066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004704348,"about_ca_system_score_gemma":0.0005355648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006164543,"about_ca_topic_score_gemma":0.002176447,"domain_scores_codex":[0.999445,0.0003288944,0.00002962549,0.00006219689,0.00005062274,0.0000835496],"domain_scores_gemma":[0.9994111,0.0001170372,0.000222275,0.00005598926,0.00003193572,0.0001616248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.899816,0.003421472,0.01176964,0.001573682,0.002186963,0.000108318,0.0001402233,0.0005367724,0.005490823,0.0001769947,0.002144616,0.07263457],"study_design_scores_gemma":[0.6729639,0.1831312,0.1297839,0.0004366578,0.00427086,0.000458223,0.0001224149,0.001362332,0.00178003,0.000261251,0.005367564,0.000061698],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872209,0.009831877,0.0001411252,0.0004055435,0.00008143239,0.000322371,0.0003862552,0.00005457381,0.0015559],"genre_scores_gemma":[0.9929435,0.002064376,0.0008251522,0.0004841068,0.0001766174,0.000593376,0.001139712,0.000007634007,0.001765516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002424836,"threshold_uncertainty_score":0.009426355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01268303488639753,"score_gpt":0.2550064268449887,"score_spread":0.2423233919585912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}