{"id":"W4365484712","doi":"10.1097/sla.0000000000005880","title":"Single-nuclei RNA Profiling Reveals Disruption of Adipokine and Inflammatory Signaling in Adipose Tissue of Burn Patients","year":2023,"lang":"en","type":"article","venue":"Annals of Surgery","topic":"Burn Injury Management and Outcomes","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; Hamilton Health Sciences; Hamilton General Hospital; Thrombosis and Atherosclerosis Research Institute; Sunnybrook Hospital","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Adipokine; Adipose tissue; Medicine; Hypermetabolism; Lipolysis; Inflammation; White adipose tissue; Internal medicine; Systemic inflammation; Burn injury; Adiponectin; Endocrinology; Population; Pathology; Leptin; Surgery; Insulin resistance; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009120571,0.0001111719,0.0005277424,0.000594651,0.00001486985,0.000003813509,0.00004457452,0.00006773461,0.00002581182],"category_scores_gemma":[0.0004071504,0.0001038591,0.00009188434,0.0004452423,0.00006154717,0.0001466872,0.00005862387,0.00007398991,0.000003198282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006965925,"about_ca_system_score_gemma":0.00001907646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002416692,"about_ca_topic_score_gemma":0.00000166713,"domain_scores_codex":[0.9985806,0.0000488274,0.0007460669,0.0001524644,0.0002729082,0.0001991683],"domain_scores_gemma":[0.9989322,0.0002993145,0.0003628237,0.0001681944,0.0001826062,0.00005489613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002294621,0.0001471564,0.8462397,0.001538965,0.00008120583,0.00001955022,0.0002457882,0.00001028435,0.1336271,0.0001083409,0.0005167596,0.01723566],"study_design_scores_gemma":[0.0004212386,0.0001441995,0.7388709,0.001246512,0.00004764637,5.309568e-7,0.0001234945,0.00003764095,0.2585664,0.0002146824,0.0002243709,0.0001023437],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986584,0.0004430732,0.000002680409,0.0002382087,0.0001022997,0.0002595072,0.00001512904,0.00002437957,0.0002562887],"genre_scores_gemma":[0.9992632,0.0003332292,0.00006363258,0.00007415436,0.00003936471,0.000005095096,0.0000510699,0.00001818625,0.0001521277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1249393,"threshold_uncertainty_score":0.4235249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1225968507859782,"score_gpt":0.3316427285323245,"score_spread":0.2090458777463463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}