{"id":"W4365511380","doi":"10.1017/s1092852923002171","title":"Impact of AXS-05 (DEXTROMETHORPHAN-BUPROPION), an Oral NMDA Receptor Antagonist, on Anhedonic Symptoms in Major Depressive Disorder","year":2023,"lang":"en","type":"article","venue":"CNS Spectrums","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brain and Cognition Discovery Foundation; University of Toronto","funders":"","keywords":"Dextromethorphan; Placebo; Bupropion; Anhedonia; Major depressive disorder; Antidepressant; Medicine; Pharmacology; Internal medicine; Antagonist; Anesthesia; Receptor; Amygdala; Smoking cessation; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002809376,0.0002899026,0.0003502449,0.0001626807,0.00008344851,0.00002566875,0.000335135,0.0002408403,0.000465384],"category_scores_gemma":[0.0001252715,0.0002262514,0.0002301362,0.0004633182,0.00009303901,0.00001469494,0.0001435867,0.0002142833,0.000101857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007364237,"about_ca_system_score_gemma":0.00009727619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001310962,"about_ca_topic_score_gemma":0.00007343731,"domain_scores_codex":[0.9981537,0.0002048612,0.0002796564,0.000584513,0.0001964991,0.0005807961],"domain_scores_gemma":[0.9992034,0.00004433034,0.0001218181,0.0003942854,0.00003987275,0.0001962269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005026265,0.0003513372,0.00860461,0.00001895902,0.00009528014,0.00001259333,0.00002642873,0.0004336402,0.9806468,0.0002258413,0.001233127,0.00784878],"study_design_scores_gemma":[0.002886426,0.00604424,0.07867212,0.00003836969,0.00002736852,0.000006305065,0.000042556,0.0006931387,0.9082443,0.0006454615,0.002217414,0.0004822883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983799,0.0001621961,0.000177585,0.00008728647,0.0003689042,0.0004243216,0.00009043395,0.00005071879,0.0002586633],"genre_scores_gemma":[0.9984687,0.0003180028,0.0001826602,0.0001047671,0.0002002577,0.00007324763,0.0003248413,0.00004464539,0.0002828801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07240246,"threshold_uncertainty_score":0.9226266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440751235173939,"score_gpt":0.3222353837493605,"score_spread":0.3078278713976211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}