{"id":"W4365511472","doi":"10.1016/j.cmet.2023.03.014","title":"Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight","year":2023,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto General Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Halpin Foundation; National Institutes of Health; Rare Diseases Clinical Research Network; University of Toronto; National Institute of Diabetes and Digestive and Kidney Diseases; Boehringer Ingelheim; University of Michigan","keywords":"GDF15; Metformin; Endocrinology; Internal medicine; Area postrema; Energy homeostasis; Glial cell line-derived neurotrophic factor; Gene knockdown; Kidney; Medicine; Biology; Diabetes mellitus; Receptor; Apoptosis; Neurotrophic factors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002425895,0.0004105872,0.0005138054,0.0003915299,0.0003054045,0.0005006038,0.0003385977,0.0005694749,0.002635208],"category_scores_gemma":[0.000257245,0.0002747772,0.0005909272,0.0001140528,0.0005147947,0.0004055448,0.0005993496,0.001380044,0.0003877057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009257949,"about_ca_system_score_gemma":0.0007257416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001394249,"about_ca_topic_score_gemma":0.003886163,"domain_scores_codex":[0.9996898,0.00002807272,0.00001694794,0.00008855991,0.0000681956,0.0001084391],"domain_scores_gemma":[0.9997547,0.00001199203,0.0000957276,0.00001888567,0.00002483507,0.00009387338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002682162,0.00009693461,0.004985533,0.000170295,0.0001000438,0.0003467163,0.0000605923,0.000172643,0.9794724,0.001569522,0.000781708,0.009561461],"study_design_scores_gemma":[0.0003771285,0.0008682516,0.1341454,0.0001083796,0.0002049962,0.000693823,0.0004212807,0.002036421,0.8343723,0.00156917,0.02514408,0.00005879903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809997,0.004734552,0.007234085,0.0008409331,0.0007120142,0.00006672479,0.001257369,0.0002875451,0.003867123],"genre_scores_gemma":[0.9840196,0.001332676,0.003954799,0.0005473254,0.00008728735,0.0001108164,0.0009330936,0.0001107826,0.008903604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002635208,"threshold_uncertainty_score":0.008815646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203811946046394,"score_gpt":0.2289198906495858,"score_spread":0.2168817711891218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}