{"id":"W4365511862","doi":"10.1158/1538-7445.am2023-lb313","title":"Abstract LB313: EGFRvIII-targeted alpha therapy shows significant therapeutic efficacy as both a single-agent and in combination with standard of care against preclinical GBM models","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Biodistribution; Cancer research; Medicine; In vivo; Targeted therapy; Radiation therapy; Spect imaging; Blood–brain barrier; Cancer; Nuclear medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756546,0.0004324511,0.0004481626,0.0003383637,0.0001675057,0.0002743707,0.0002884543,0.0003697771,0.001294065],"category_scores_gemma":[0.00008542874,0.0001120068,0.0002431628,0.0002571577,0.0002076858,0.0001785161,0.0001552273,0.0008482275,0.0004001294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004039765,"about_ca_system_score_gemma":0.0004324018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002466128,"about_ca_topic_score_gemma":0.00268931,"domain_scores_codex":[0.9998268,0.00002845003,0.00001195241,0.00002774698,0.00005763103,0.00004741892],"domain_scores_gemma":[0.9999335,0.000005888339,0.00001713385,0.000007152525,0.000009292698,0.00002698269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001034069,0.0007050892,0.0002250409,0.0000575966,0.00002184676,0.00004920061,0.00001854782,0.0003737546,0.989569,0.0001077384,0.0007198223,0.007118298],"study_design_scores_gemma":[0.00008924372,0.003616631,0.001870778,0.000006359761,0.0000243859,0.0001788687,0.000008507606,0.001329355,0.990453,0.0000211173,0.002393433,0.000008244714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915472,0.002680341,0.002015453,0.0001895671,0.00008636673,0.00009217551,0.000575952,0.0004158,0.002397172],"genre_scores_gemma":[0.9929362,0.0009880699,0.002017984,0.00005661356,0.00001748826,0.00005794622,0.0009127731,0.00004198177,0.002970911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002466128,"threshold_uncertainty_score":0.004903555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2116112382254819,"score_gpt":0.4703029994853052,"score_spread":0.2586917612598233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}