{"id":"W4365512024","doi":"10.1158/1538-7445.am2023-ct266","title":"Abstract CT266: Chinese race and origin have no clinically meaningful effect on tiragolumab and atezolizumab pharmacokinetics and safety in patients with advanced solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Atezolizumab; Medicine; Dosing; Adverse effect; Internal medicine; Pharmacokinetics; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000730099,0.0003354005,0.0006279892,0.000177665,0.0002956224,0.0004082482,0.0002307552,0.0003119424,0.007594048],"category_scores_gemma":[0.0008614131,0.000116438,0.0008098273,0.0003893928,0.0003501329,0.0003204216,0.0002423148,0.0006767343,0.0009089287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005381318,"about_ca_system_score_gemma":0.001240267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002647134,"about_ca_topic_score_gemma":0.004419222,"domain_scores_codex":[0.9996294,0.0001300684,0.00003079096,0.00007871241,0.00007226536,0.00005888769],"domain_scores_gemma":[0.9994615,0.0001117424,0.0001654459,0.00006219114,0.00006626252,0.0001328256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3512534,0.004790341,0.3644646,0.0007997371,0.002541398,0.001242429,0.0005144955,0.001348251,0.1360159,0.0004866456,0.008571239,0.1279715],"study_design_scores_gemma":[0.01382684,0.04643092,0.911814,0.00006222539,0.001405827,0.001200051,0.000217108,0.001305908,0.01382268,0.0002434822,0.009623925,0.00004703841],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943867,0.001183953,0.0002712598,0.0002449614,0.00004328178,0.0001248649,0.0009646214,0.00002751286,0.002752829],"genre_scores_gemma":[0.9961329,0.0002131873,0.0002134098,0.0002476891,0.00003511887,0.00007533746,0.00116517,0.00001852064,0.001898678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007594048,"threshold_uncertainty_score":0.02540463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02831565334505279,"score_gpt":0.4150989559091454,"score_spread":0.3867833025640926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}