{"id":"W4365512035","doi":"10.1158/1538-7445.am2023-ct212","title":"Abstract CT212: A ctDNA-directed, multi-center phase II study of molecular response adaptive immuno-chemotherapy in patients with non-small cell lung cancer: Analysis of Stage 1 of CCTG BR.36","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Kingston Health Sciences Centre; Ottawa Hospital; Princess Margaret Cancer Centre; University Health Network; Hamilton Health Sciences; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Oncology; Internal medicine; Liquid biopsy; Lung cancer; Chemotherapy; Response Evaluation Criteria in Solid Tumors; Chemotherapy regimen; Cancer; Stage (stratigraphy); Pembrolizumab; Clinical endpoint; Phases of clinical research; Clinical trial; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002665708,0.001761724,0.001705321,0.0004164401,0.0005609363,0.0008620454,0.001201104,0.001273561,0.005274737],"category_scores_gemma":[0.001365119,0.0006171304,0.001134426,0.0005514966,0.0006820699,0.0005468344,0.0003927861,0.003069568,0.001462013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001579809,"about_ca_system_score_gemma":0.003130616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003179807,"about_ca_topic_score_gemma":0.007562264,"domain_scores_codex":[0.999024,0.0005082985,0.00004650476,0.0001804866,0.0001145972,0.0001261902],"domain_scores_gemma":[0.9987904,0.0001100065,0.0001847658,0.0001077442,0.0001437663,0.0006633784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7451413,0.06448752,0.02754988,0.0009739353,0.001182592,0.0002790838,0.0003355011,0.002619359,0.09365592,0.0002581866,0.00920303,0.0543137],"study_design_scores_gemma":[0.4845685,0.4600392,0.04327882,0.00005204504,0.0005440551,0.0003998498,0.00005156148,0.001152106,0.005994966,0.0001448925,0.00372509,0.00004895282],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814867,0.001003852,0.000789261,0.0006388485,0.0001259202,0.008170097,0.005225701,0.0001337478,0.002425832],"genre_scores_gemma":[0.9688265,0.0006954951,0.003408313,0.001497265,0.0002246768,0.007966055,0.01059422,0.00007708556,0.006710432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005274737,"threshold_uncertainty_score":0.01764578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02662843555151254,"score_gpt":0.359848052435867,"score_spread":0.3332196168843545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}