{"id":"W4365512087","doi":"10.1158/1538-7445.am2023-ct234","title":"Abstract CT234: A phase I/II trial investigating safety and efficacy of autologous TAC01-HER2 in relapsed or refractory solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Chimeric antigen receptor; Breast cancer; Cancer; Leukapheresis; Immunotherapy; T cell; Clinical trial; Oncology; Cancer research; Internal medicine; Immunology; Immune system; Stem cell; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007161679,0.001447997,0.001150955,0.0003694072,0.0003750036,0.001011129,0.0008852881,0.000918516,0.007315611],"category_scores_gemma":[0.0005844143,0.0002919896,0.0008451508,0.0004422551,0.000899887,0.0005818687,0.0003106002,0.002834813,0.001837945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009100938,"about_ca_system_score_gemma":0.001685019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041875,"about_ca_topic_score_gemma":0.001642406,"domain_scores_codex":[0.9997407,0.0001199737,0.00001420794,0.00004248038,0.00002928412,0.00005333658],"domain_scores_gemma":[0.9995993,0.00004512805,0.00006005404,0.00003436725,0.00002280832,0.0002383822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6937258,0.0422385,0.007051181,0.001949129,0.001588234,0.001191351,0.0002729355,0.004662143,0.1286979,0.0008994106,0.01152379,0.1061996],"study_design_scores_gemma":[0.4953448,0.4704454,0.008156619,0.00009859508,0.0005253946,0.001287835,0.00008145696,0.001371718,0.01525016,0.0004025525,0.006984285,0.00005118139],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865105,0.001702463,0.0006837751,0.0006322098,0.0001450227,0.002754417,0.003122915,0.0001895176,0.004259321],"genre_scores_gemma":[0.9837332,0.001396774,0.001145794,0.0007469098,0.0001418892,0.002320801,0.00548418,0.00003701156,0.004993382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007315611,"threshold_uncertainty_score":0.02447313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1629050150414387,"score_gpt":0.4863830338915728,"score_spread":0.3234780188501341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}