{"id":"W4365512104","doi":"10.1158/1538-7445.am2023-lb362","title":"Abstract LB362: Epigenome-wide DNA methylation alterations precede diagnosis since birth and affect prognosis of pediatric B-cell acute lymphoblastic leukemia","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Epigenome; DNA methylation; Oncology; Leukemia; Methylation; Population; Biology; Acute leukemia; Cancer; Medicine; Bioinformatics; Cancer research; Internal medicine; Immunology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398252,0.0002050315,0.0001847816,0.0004281191,0.0001877881,0.0002753663,0.0001868853,0.000197002,0.001817993],"category_scores_gemma":[0.0005992265,0.0001143524,0.0001724781,0.0005233163,0.0001277437,0.0001404413,0.0002301088,0.0002405156,0.0003286808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000247826,"about_ca_system_score_gemma":0.0002124198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002099403,"about_ca_topic_score_gemma":0.002223558,"domain_scores_codex":[0.9998401,0.00003252323,0.00001352326,0.00006309521,0.00002597797,0.00002471607],"domain_scores_gemma":[0.9997765,0.00004212281,0.00009013442,0.00002394228,0.00002691965,0.00004032503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001418112,0.00003817179,0.9233442,0.00005738818,0.00007829214,0.0001909176,0.0001155682,0.0002479317,0.06539485,0.0000437396,0.0002813604,0.008789469],"study_design_scores_gemma":[0.000009068744,0.000126779,0.989454,0.000004929293,0.00004011936,0.0005709274,0.00005183257,0.0002431141,0.008833515,0.00003784161,0.0006247046,0.000003145089],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971926,0.0005882776,0.0006386954,0.00004440953,0.000005527947,0.00000750646,0.001199171,0.00001634984,0.0003073676],"genre_scores_gemma":[0.997285,0.0002025584,0.0005709305,0.00002514294,0.000006067658,0.00001543886,0.001333667,0.000008497414,0.0005526987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002099403,"threshold_uncertainty_score":0.00608182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04158526941162493,"score_gpt":0.3560426376277204,"score_spread":0.3144573682160955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}