{"id":"W4365512210","doi":"10.1158/1538-7445.am2023-ct278","title":"Abstract CT278: <i>ERBB2</i> amplification detected in ctDNA as a surrogate for tumor tissue FISH analysis of HER2 status in a phase 1 study with zanidatamab for the treatment of locally advanced or metastatic HER2 expressing cancers","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Concordance; Cancer; Gene duplication; Cancer research; Breast cancer; Medicine; Copy-number variation; Biology; Colorectal cancer; Gene; Oncology; Internal medicine; Genome; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00115871,0.0006060465,0.0005236082,0.0003146143,0.0002964374,0.0004153942,0.0004580299,0.0005631577,0.004596869],"category_scores_gemma":[0.0006230809,0.0002730601,0.0003740305,0.0003165908,0.0006096014,0.0003257407,0.0001787837,0.001618036,0.0007991776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000906805,"about_ca_system_score_gemma":0.0008430869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001388343,"about_ca_topic_score_gemma":0.003009056,"domain_scores_codex":[0.9995745,0.0001506452,0.00003050152,0.00009379552,0.00009651862,0.00005399812],"domain_scores_gemma":[0.9996256,0.00007632213,0.00007445827,0.00003642769,0.00006388401,0.0001233746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1269247,0.007947945,0.02765015,0.0007314874,0.0007942318,0.0008594895,0.0002661753,0.004387175,0.7566406,0.0004907296,0.009748474,0.0635589],"study_design_scores_gemma":[0.07786411,0.3437816,0.1603989,0.0001003353,0.001753526,0.006492297,0.0002865365,0.008880807,0.3697167,0.000758086,0.0298539,0.0001133253],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860889,0.001267554,0.002765339,0.0004717809,0.00007875607,0.001961465,0.002760283,0.0001274277,0.004478432],"genre_scores_gemma":[0.9896801,0.0004242386,0.002462674,0.0003614541,0.00002135493,0.001212806,0.002788797,0.00006297763,0.002985588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004596869,"threshold_uncertainty_score":0.015378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06689138497758919,"score_gpt":0.4319311904659967,"score_spread":0.3650398054884075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}