{"id":"W4365512223","doi":"10.1158/1538-7445.am2023-ct229","title":"Abstract CT229: CRESTONE: A Phase 2 study of seribantumab in adult patients with neuregulin-1 (NRG1) fusion positive locally advanced or metastatic solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"","keywords":"Medicine; Cohort; Internal medicine; Oncology; Cancer; Response Evaluation Criteria in Solid Tumors; ErbB; Adenocarcinoma; Cancer research; Phases of clinical research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007040295,0.0009712244,0.0008395364,0.0002514815,0.0002566374,0.0007529021,0.0005513419,0.0006689994,0.003161358],"category_scores_gemma":[0.0004596574,0.0002959255,0.0007751365,0.0002717962,0.0003674669,0.0003728952,0.0002943038,0.001697576,0.0006590614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007296956,"about_ca_system_score_gemma":0.001192661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00190321,"about_ca_topic_score_gemma":0.007200285,"domain_scores_codex":[0.9998038,0.00007021341,0.00001416825,0.00003519025,0.00003405549,0.00004245034],"domain_scores_gemma":[0.9996626,0.00003508041,0.00005856291,0.00002106876,0.00003979194,0.0001829281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4182633,0.05497367,0.04988422,0.001905902,0.003112611,0.001856405,0.000824154,0.006284938,0.229625,0.0006132541,0.02301916,0.2096375],"study_design_scores_gemma":[0.3286022,0.5245363,0.105472,0.0001608553,0.001394506,0.002566397,0.0001962371,0.004170361,0.01857767,0.0002277139,0.01400202,0.00009378403],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925634,0.001421968,0.0003212257,0.0002595965,0.00004758847,0.001230359,0.001861432,0.0000989804,0.00219537],"genre_scores_gemma":[0.9888848,0.001179002,0.000956862,0.0005944273,0.00004862893,0.0007606572,0.004513605,0.00002114822,0.00304085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003161358,"threshold_uncertainty_score":0.01057583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.076277487442443,"score_gpt":0.4803886962775271,"score_spread":0.4041112088350841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}