{"id":"W4365512265","doi":"10.1158/1538-7445.am2023-ct110","title":"Abstract CT110: Safety and anti-tumor activity of a novel Treg depleter RG6292, as a single agent and in combination with atezolizumab in patients with solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); BC Cancer Agency; Princess Margaret Cancer Centre; Ottawa Hospital","funders":"","keywords":"Medicine; Rash; Adverse effect; Atezolizumab; Internal medicine; Gastroenterology; Surgery; Cancer; Nivolumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002999013,0.0003366242,0.0006481156,0.0001699234,0.0001161102,0.0003681668,0.0002202165,0.0002797654,0.002215083],"category_scores_gemma":[0.0003228419,0.0001160253,0.000416512,0.0002024896,0.0002012621,0.0002416907,0.0001439173,0.0008548297,0.0004787347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000321118,"about_ca_system_score_gemma":0.0004584617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004939053,"about_ca_topic_score_gemma":0.0008987148,"domain_scores_codex":[0.9998927,0.00003336163,0.00001125852,0.00002138319,0.00002206929,0.00001921704],"domain_scores_gemma":[0.9998412,0.00003011811,0.00004068558,0.00001501331,0.00001355727,0.00005939129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1766184,0.01154481,0.02068843,0.001432832,0.0007555399,0.0008278356,0.0001966608,0.006391345,0.3608096,0.0003209783,0.009535798,0.4108778],"study_design_scores_gemma":[0.06710491,0.68423,0.08310405,0.0001379768,0.001157046,0.003222366,0.0001177364,0.009168659,0.1359646,0.0002390457,0.01548332,0.00007036045],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99431,0.002872191,0.0003732933,0.0001305675,0.00004225659,0.0001263405,0.0005609226,0.00009875971,0.001485494],"genre_scores_gemma":[0.9969373,0.0007270098,0.0003293313,0.0001170754,0.00003143072,0.00005932569,0.0008013606,0.00000850451,0.0009888133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002215083,"threshold_uncertainty_score":0.007410228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05323121672667343,"score_gpt":0.3570217725360503,"score_spread":0.3037905558093769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}