{"id":"W4365512273","doi":"10.1158/1538-7445.am2023-ct206","title":"Abstract CT206: A phase I study of binimetinib, a MEK inhibitor, in combination with pembrolizumab in patients with advanced non-small cell lung cancer (NSCLC)","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baker Hughes (Canada); Niagara Health System; Windsor Regional Hospital; North York General Hospital; Grand River Hospital; St Joseph's Health Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Rash; Pembrolizumab; Internal medicine; KRAS; Response Evaluation Criteria in Solid Tumors; Oncology; Lung cancer; Adverse effect; MEK inhibitor; Gastroenterology; Cancer; Phases of clinical research; Clinical trial; Kinase; MAPK/ERK pathway; Immunotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007720036,0.001237391,0.001473518,0.0003718088,0.0005379507,0.0008951341,0.0007143748,0.0008972452,0.003588665],"category_scores_gemma":[0.000450901,0.0005099479,0.0008537499,0.0004054145,0.0006583052,0.0005649913,0.000294336,0.002808533,0.0009956496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009480819,"about_ca_system_score_gemma":0.001484036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0011983,"about_ca_topic_score_gemma":0.003266186,"domain_scores_codex":[0.9997336,0.000110632,0.00001890629,0.00004488507,0.00003288528,0.00005905986],"domain_scores_gemma":[0.9996251,0.00003589885,0.0000478857,0.00002041374,0.00002626852,0.0002444513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6043941,0.1074028,0.01298403,0.001131765,0.001249986,0.0007602957,0.0004643607,0.003733616,0.1670106,0.0004016127,0.005252912,0.09521403],"study_design_scores_gemma":[0.3049226,0.6586714,0.01731791,0.00004030511,0.0004752951,0.000700088,0.00006241148,0.001277808,0.0130368,0.0001011909,0.003354318,0.00003986526],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941216,0.0008883018,0.0003347049,0.0002845793,0.00007241325,0.001604203,0.0008206142,0.00007196191,0.001801548],"genre_scores_gemma":[0.9911014,0.0007563952,0.001185023,0.0004559178,0.0000836832,0.001555837,0.001945145,0.00001951536,0.002897061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003588665,"threshold_uncertainty_score":0.01200533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269849598645779,"score_gpt":0.4195021822245747,"score_spread":0.3868036862381169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}