{"id":"W4365512579","doi":"10.1016/j.celrep.2023.112399","title":"Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; Saskatchewan Health Research Foundation","keywords":"NRF1; Cholesterol; Gene; Cell biology; Biology; Internal medicine; Transcription factor; Chemistry; Endocrinology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213326,0.0003320223,0.0003891571,0.0002216118,0.0001362808,0.0002028014,0.0001756529,0.0002110444,0.001779088],"category_scores_gemma":[0.0001163075,0.000125198,0.0002161847,0.0001197422,0.0002496271,0.000274546,0.0001743208,0.0003837237,0.0002925893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617018,"about_ca_system_score_gemma":0.0001785855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493154,"about_ca_topic_score_gemma":0.0005489089,"domain_scores_codex":[0.9998963,0.00001886179,0.000009100663,0.000030096,0.00002145456,0.00002424923],"domain_scores_gemma":[0.9998833,0.00001180406,0.00003551036,0.00001805498,0.00002031448,0.00003106682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003292772,0.0000436792,0.0002714022,0.00005412624,0.00000996757,0.00003119624,0.00001187395,0.00002457412,0.9967976,0.0001322132,0.00004582197,0.002248246],"study_design_scores_gemma":[0.00006207086,0.001109018,0.008142861,0.0000130372,0.00004695593,0.000367299,0.00005768011,0.0004859633,0.9848195,0.0001977713,0.004689081,0.000008673434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915296,0.002209175,0.004173059,0.0003483896,0.00006247412,0.00002638409,0.0003348848,0.0001581181,0.001157847],"genre_scores_gemma":[0.991323,0.001114996,0.003465197,0.0001237201,0.0000174111,0.00003785878,0.0004157393,0.0000226111,0.003479426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779088,"threshold_uncertainty_score":0.005951643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008266676161544806,"score_gpt":0.2248247658262003,"score_spread":0.2165580896646555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}