{"id":"W4365512579","doi":"10.1016/j.celrep.2023.112399","title":"Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; Saskatchewan Health Research Foundation","keywords":"NRF1; Cholesterol; Gene; Cell biology; Biology; Internal medicine; Transcription factor; Chemistry; Endocrinology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463197,0.000152748,0.0001395181,0.00003169611,0.00008292805,0.00002549645,0.00006362038,0.00008960228,0.00001140645],"category_scores_gemma":[0.0000286617,0.0001593394,0.00004645301,0.00006405496,0.00006346532,0.000004720463,0.0001309136,0.00006067958,0.000007214979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001752527,"about_ca_system_score_gemma":0.00002854099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002310503,"about_ca_topic_score_gemma":0.000009522706,"domain_scores_codex":[0.9988999,0.00003194658,0.0002784067,0.0004424312,0.0001198135,0.000227491],"domain_scores_gemma":[0.9993266,0.000006455997,0.0001737786,0.0003556469,0.0000455986,0.0000918589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001254383,0.0000278012,0.007765363,0.00004441103,0.0000183375,0.00001822499,0.00004438815,0.00002497259,0.9808853,4.242702e-7,0.01007372,0.001084566],"study_design_scores_gemma":[0.0003000494,0.00006875891,0.01250753,0.00001273154,0.000009301123,0.00001613999,0.00003380915,0.00006711004,0.9705554,0.0001532635,0.01609608,0.0001797736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979885,0.0003711774,0.0001824068,0.00007038924,0.0001195514,0.0004210254,0.00003323157,0.00002645084,0.0007872773],"genre_scores_gemma":[0.9963956,0.0002071891,0.0002715712,0.0002230395,0.0001496148,0.00004574248,0.001675995,0.00002474234,0.001006438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0103298,"threshold_uncertainty_score":0.649767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008266676161544806,"score_gpt":0.2248247658262003,"score_spread":0.2165580896646555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}