{"id":"W4365512763","doi":"10.1158/1538-7445.am2023-ct058","title":"Abstract CT058: TROPION-PanTumor03: Phase 2, multicenter study of datopotamab deruxtecan (Dato-DXd) as monotherapy and in combination with anticancer agents in patients (pts) with advanced/metastatic solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nivolumab; Prostate cancer; Internal medicine; Combination therapy; Cancer; Oncology; Bevacizumab; Phases of clinical research; Immunotherapy; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001448557,0.001628292,0.001216667,0.0005020179,0.000409038,0.001123598,0.001054323,0.00128822,0.00515499],"category_scores_gemma":[0.0007741314,0.0005628684,0.001099312,0.000598231,0.0008255911,0.000844776,0.0003600766,0.003057228,0.001411218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001351286,"about_ca_system_score_gemma":0.001696415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001850838,"about_ca_topic_score_gemma":0.004179415,"domain_scores_codex":[0.9995903,0.0002024183,0.00001943196,0.00006701337,0.00004504436,0.00007575715],"domain_scores_gemma":[0.999424,0.0000667857,0.0001115407,0.0000456523,0.00004480497,0.0003072643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7112346,0.07446562,0.01236473,0.00091572,0.001838354,0.0004253901,0.0004171165,0.003536575,0.0931215,0.0004690823,0.01132426,0.08988699],"study_design_scores_gemma":[0.5415701,0.4270045,0.01608113,0.00004845961,0.0006014123,0.0005695067,0.00008881438,0.00157958,0.007506342,0.0002142133,0.004695396,0.00004058041],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884611,0.001834313,0.0005996465,0.0005695441,0.00008963908,0.002470496,0.003561406,0.0001896941,0.002224091],"genre_scores_gemma":[0.9815835,0.001494453,0.001959467,0.0009662912,0.0001512987,0.002744445,0.006929379,0.00006628918,0.004104843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00515499,"threshold_uncertainty_score":0.01724517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07314861898670705,"score_gpt":0.47179241001322,"score_spread":0.398643791026513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}