{"id":"W4365512763","doi":"10.1158/1538-7445.am2023-ct058","title":"Abstract CT058: TROPION-PanTumor03: Phase 2, multicenter study of datopotamab deruxtecan (Dato-DXd) as monotherapy and in combination with anticancer agents in patients (pts) with advanced/metastatic solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nivolumab; Prostate cancer; Internal medicine; Combination therapy; Cancer; Oncology; Bevacizumab; Phases of clinical research; Immunotherapy; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007438419,0.0002739722,0.0006850185,0.001133827,0.0001289901,0.00004229781,0.0002327269,0.00003827399,0.0001032304],"category_scores_gemma":[0.0002540606,0.000202547,0.00002642803,0.001999241,0.0003660051,0.00029929,0.0001554114,0.0006544282,0.00001198528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007425185,"about_ca_system_score_gemma":0.0006286066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002985856,"about_ca_topic_score_gemma":0.004024584,"domain_scores_codex":[0.9958633,0.0002431282,0.0005293476,0.0007058594,0.001776063,0.0008823167],"domain_scores_gemma":[0.998292,0.0002854579,0.0001427026,0.0004732336,0.0005834716,0.0002231126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01880715,0.006413147,0.9426793,0.001037114,0.0003259274,0.000740224,0.006542027,0.0002984523,0.00219843,0.000007911784,0.0002406086,0.02070975],"study_design_scores_gemma":[0.06343371,0.0083118,0.9155102,0.001826043,0.00003336993,0.000002755151,0.006625632,0.000603696,0.003285985,0.00005146411,0.00007967,0.000235668],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994918,0.0003196741,0.000003388307,0.0005170444,0.00003796863,0.004049962,0.00004571084,0.00003348395,0.00007471384],"genre_scores_gemma":[0.9970233,0.001521008,0.00004662483,0.00004834615,0.00002131439,0.001113832,0.00003582884,0.000071098,0.0001186344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04462656,"threshold_uncertainty_score":0.8259627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07314861898670705,"score_gpt":0.47179241001322,"score_spread":0.398643791026513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}