{"id":"W4365513111","doi":"10.3390/vaccines11040841","title":"Development of an Integrated Continuous Manufacturing Process for the rVSV-Vectored SARS-CoV-2 Candidate Vaccine","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Research Council Canada; Canada Research Chairs","keywords":"Vesicular stomatitis virus; Downstream processing; Viral vector; Batch processing; Process (computing); Virology; Biology; Recombinant DNA; Computer science; Chemistry; Chromatography; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005280603,0.000249497,0.0004633125,0.0003116939,0.0001862775,0.00003887836,0.0003529576,0.00009929195,0.000008220442],"category_scores_gemma":[0.0002481933,0.0001516256,0.00009554909,0.0006188008,0.0000190113,0.0001107924,0.00008264396,0.0001881721,0.00003257953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006853742,"about_ca_system_score_gemma":0.000410845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003083603,"about_ca_topic_score_gemma":0.0009727616,"domain_scores_codex":[0.9982587,0.00002963015,0.0004851112,0.0003800445,0.000349858,0.0004966398],"domain_scores_gemma":[0.9988557,0.0001986617,0.0001275418,0.0004317237,0.0003499172,0.0000364537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004169273,0.0003277101,0.01697855,0.001060686,0.0006196151,0.0000825879,0.004330403,0.0000102548,0.8800644,0.00002109438,0.003652767,0.08868265],"study_design_scores_gemma":[0.002524747,0.0001900135,0.0248913,0.00009644133,0.00006431896,0.00001897709,0.001049152,0.00166105,0.8839919,0.00005484884,0.08529056,0.0001666883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973665,0.0001894701,0.0002914509,0.0004666464,0.0001873223,0.001161984,0.00002039485,0.0002252755,0.00009091499],"genre_scores_gemma":[0.996374,0.000007694444,0.0004499417,0.002441887,0.0001923602,0.0003139801,0.00005457912,0.00005971055,0.0001059216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08851597,"threshold_uncertainty_score":0.6183111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05579290087375072,"score_gpt":0.3683092581403512,"score_spread":0.3125163572666005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}