{"id":"W4365513372","doi":"10.1158/1538-7445.am2023-ct037","title":"Abstract CT037: Nivolumab plus ipilimumab vs chemotherapy as first-line treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma: CheckMate 649 biomarker analyses","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Nivolumab; Medicine; Internal medicine; Oncology; Cancer; Ipilimumab; Pemetrexed; Biomarker; Chemotherapy; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071265,0.0004181102,0.00101924,0.0003038284,0.0001855229,0.0005912886,0.0004574648,0.0006206263,0.003741019],"category_scores_gemma":[0.0011222,0.0001591734,0.001414871,0.0003474293,0.0003041348,0.0003333007,0.0002759644,0.0008695339,0.0002876883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001130412,"about_ca_system_score_gemma":0.0006870993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001651028,"about_ca_topic_score_gemma":0.003438859,"domain_scores_codex":[0.9995975,0.0002001485,0.00002839267,0.00007844051,0.00004464553,0.00005084744],"domain_scores_gemma":[0.9991646,0.0002460675,0.0001977072,0.00005436374,0.00005823041,0.0002790819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9025401,0.003052195,0.0228227,0.0003922691,0.003274833,0.00006266646,0.00005968474,0.003022975,0.0177881,0.000152866,0.001886201,0.04494536],"study_design_scores_gemma":[0.2374907,0.4749117,0.2295,0.0001861584,0.01370784,0.0003415218,0.0001650233,0.01498133,0.02060604,0.0006289639,0.007387706,0.00009313777],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968044,0.00102082,0.0001423041,0.0001504732,0.00005118323,0.0001867871,0.0008752277,0.00002395124,0.0007449567],"genre_scores_gemma":[0.9973797,0.0002091196,0.0002537128,0.000176985,0.00003809986,0.000209975,0.0009789297,0.000006664487,0.0007469315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003741019,"threshold_uncertainty_score":0.01251495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1584976595064492,"score_gpt":0.4607322598945875,"score_spread":0.3022346003881383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}