{"id":"W4365514035","doi":"10.1158/1538-7445.am2023-ct026","title":"Abstract CT026: A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH, in advanced myeloid malignancies","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Gastroenterology; IDH1; Pharmacology; Myeloid; Oncology; Mutant; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001166292,0.001421393,0.001199603,0.0004306029,0.0004453235,0.0008164981,0.0009025202,0.000955853,0.004932419],"category_scores_gemma":[0.0006369113,0.0003966574,0.0006106269,0.000414537,0.0008854952,0.0006085093,0.0003488869,0.003096476,0.001104312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009512759,"about_ca_system_score_gemma":0.00162578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001426933,"about_ca_topic_score_gemma":0.002891625,"domain_scores_codex":[0.9996583,0.0001593305,0.00001808807,0.00005154876,0.00004403492,0.00006858425],"domain_scores_gemma":[0.9995332,0.00007866177,0.00007495021,0.00003968697,0.0000376522,0.0002358414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3207035,0.1057349,0.01310805,0.001304094,0.0009858003,0.001195527,0.000627109,0.006640177,0.3533251,0.0009017555,0.01696463,0.1785092],"study_design_scores_gemma":[0.2661458,0.6591398,0.01783176,0.00006401792,0.0003483335,0.00135039,0.00008598736,0.002691244,0.04435182,0.0002327813,0.00771433,0.00004378063],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893405,0.001738207,0.001012845,0.0004884394,0.00007420544,0.002500354,0.002097297,0.000199669,0.002548571],"genre_scores_gemma":[0.9808374,0.001751637,0.003195788,0.0007328068,0.0001551008,0.002158014,0.005895154,0.00006833993,0.005205895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004932419,"threshold_uncertainty_score":0.01650065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09156463445167855,"score_gpt":0.4493115501688034,"score_spread":0.3577469157171249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}