{"id":"W4365514037","doi":"10.1158/1538-7445.am2023-ct018","title":"Abstract CT018: Safety and efficacy of three PARP inhibitors (PARPi) combined with the ataxia telangiectasia- and Rad3-related kinase inhibitor (ATRi) camonsertib in patients (pts) with solid tumors harboring DNA damage response (DDR) alterations","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Olaparib; Internal medicine; Tolerability; Response Evaluation Criteria in Solid Tumors; Neutropenia; Oncology; Phases of clinical research; Clinical trial; Chemotherapy; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004976621,0.000685938,0.000881933,0.0003388331,0.0002122791,0.0005208652,0.0005075217,0.0005047988,0.005495591],"category_scores_gemma":[0.0007303266,0.0002133141,0.0004935643,0.0003790762,0.0005235466,0.0004870663,0.0002523161,0.001331199,0.0007083991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009418964,"about_ca_system_score_gemma":0.001252169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017904,"about_ca_topic_score_gemma":0.001863434,"domain_scores_codex":[0.9997565,0.00009258818,0.00002143961,0.0000543243,0.00004024454,0.0000348556],"domain_scores_gemma":[0.9996315,0.00006191074,0.00009708192,0.00002756812,0.00002929567,0.0001524945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6880608,0.01734062,0.01342191,0.0007668938,0.0006033787,0.000278368,0.0001548603,0.004316792,0.1149355,0.0004195324,0.004920518,0.1547808],"study_design_scores_gemma":[0.1739899,0.7445128,0.03237768,0.00008441664,0.0009927901,0.0008424764,0.0000756509,0.004132326,0.03630964,0.0002794612,0.006351575,0.00005125605],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940287,0.001113536,0.0005118941,0.000142143,0.00004173838,0.0005998176,0.001210887,0.00009715632,0.002254197],"genre_scores_gemma":[0.9950597,0.0003614115,0.0007060966,0.0001029813,0.0000389477,0.0005194267,0.001704923,0.00001350777,0.001492962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005495591,"threshold_uncertainty_score":0.01838452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03680148951694935,"score_gpt":0.3467089894691543,"score_spread":0.309907499952205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}