{"id":"W4365514056","doi":"10.1158/1538-7445.am2023-ct028","title":"Abstract CT028: A first-in-human phase 1 study of LY3537982, a highly selective and potent KRAS G12C inhibitor in patients with KRAS G12C-mutant advanced solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"","keywords":"Medicine; KRAS; Internal medicine; Neutropenia; Adverse effect; Cetuximab; Gastroenterology; Nausea; Oncology; Cancer; Colorectal cancer; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001013465,0.001900423,0.001386059,0.0005239532,0.0005640034,0.001017937,0.0009361928,0.001153826,0.005991287],"category_scores_gemma":[0.000616555,0.0005326533,0.0008343609,0.0005138837,0.0008142243,0.0007719267,0.000336233,0.003464428,0.001706092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001217748,"about_ca_system_score_gemma":0.002144015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002338271,"about_ca_topic_score_gemma":0.005118309,"domain_scores_codex":[0.9997018,0.0001158312,0.00001762967,0.00005692055,0.00003419791,0.00007356701],"domain_scores_gemma":[0.9995303,0.00005904853,0.00006192685,0.00003514601,0.00004652456,0.0002670533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4552166,0.09043606,0.01416739,0.001559405,0.00144088,0.001100404,0.0006884636,0.005225722,0.2443462,0.0007598898,0.02792046,0.1571384],"study_design_scores_gemma":[0.368696,0.5720507,0.01977972,0.00009339417,0.0005597442,0.001208701,0.0001004099,0.002445855,0.02522902,0.0002526879,0.009523463,0.00006027998],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832379,0.002396151,0.0009416231,0.000721668,0.0001094601,0.003579642,0.004464546,0.0003364904,0.004212518],"genre_scores_gemma":[0.9739457,0.001802905,0.002456286,0.001067068,0.0001558954,0.002935085,0.009730761,0.0000934878,0.007812846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005991287,"threshold_uncertainty_score":0.02004284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04016513602020642,"score_gpt":0.4080571464614021,"score_spread":0.3678920104411957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}