{"id":"W4365514056","doi":"10.1158/1538-7445.am2023-ct028","title":"Abstract CT028: A first-in-human phase 1 study of LY3537982, a highly selective and potent KRAS G12C inhibitor in patients with KRAS G12C-mutant advanced solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"","keywords":"Medicine; KRAS; Internal medicine; Neutropenia; Adverse effect; Cetuximab; Gastroenterology; Nausea; Oncology; Cancer; Colorectal cancer; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004068235,0.0002525289,0.0006845453,0.0006518491,0.0002032061,0.00002098277,0.000105063,0.00005482527,0.00003678174],"category_scores_gemma":[0.0001006842,0.0001837343,0.00004153835,0.00152965,0.0001971488,0.0001093543,0.0001551015,0.0004667417,0.000004559928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009575151,"about_ca_system_score_gemma":0.0003435609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004402416,"about_ca_topic_score_gemma":0.01208042,"domain_scores_codex":[0.9972768,0.0000825688,0.0004315727,0.0006041582,0.000930958,0.0006739728],"domain_scores_gemma":[0.9988894,0.0001486673,0.00009701926,0.0002569164,0.0004377024,0.0001702623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01447183,0.007393152,0.9387887,0.0004679489,0.0004598651,0.0008495903,0.01713855,0.0001679648,0.006457466,0.000007234079,0.0003429913,0.01345469],"study_design_scores_gemma":[0.02598848,0.01259851,0.9502519,0.0007512656,0.00003891306,0.000001372135,0.004836074,0.00002256792,0.005198909,0.00003072273,0.0001011318,0.0001801998],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959292,0.0004300866,9.519495e-8,0.0003148515,0.00005755065,0.002848275,0.00005884208,0.00003287206,0.0003282201],"genre_scores_gemma":[0.9983395,0.0002370249,0.00000490771,0.00001446851,0.00005684779,0.001143027,0.00001804219,0.00003993532,0.0001462245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01327449,"threshold_uncertainty_score":0.7492467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04016513602020642,"score_gpt":0.4080571464614021,"score_spread":0.3678920104411957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}