{"id":"W4365515216","doi":"10.1080/2162402x.2023.2201147","title":"Neoadjuvant immune checkpoint blockade triggers persistent and systemic T <sub>reg</sub> activation which blunts therapeutic efficacy against metastatic spread of breast tumors","year":2023,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, British Columbia; Ministerie van Volksgezondheid, Welzijn en Sport; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; F. Hoffmann-La Roche; Oncode Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Medicine; Immune checkpoint; Breast cancer; Immune system; Cancer research; Metastatic breast cancer; Metastasis; Primary tumor; Cancer; Immunotherapy; Blockade; Oncology; CD8; Internal medicine; Immunology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097864,0.0003114993,0.0004573988,0.0001153892,0.00008390373,0.0002654418,0.0001125807,0.0002066874,0.001112223],"category_scores_gemma":[0.0001351958,0.0001404891,0.0002002421,0.00007135917,0.0002110929,0.0001692601,0.0001266025,0.001082307,0.0003278664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601562,"about_ca_system_score_gemma":0.000281102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002552261,"about_ca_topic_score_gemma":0.0006147047,"domain_scores_codex":[0.9999043,0.00001363882,0.000006636294,0.00001497244,0.00002044813,0.00003998695],"domain_scores_gemma":[0.9999217,0.00001550082,0.00002231179,0.00001021997,0.000004009547,0.00002621939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001102194,0.0003958349,0.0005478724,0.00009311202,0.00001244573,0.00009528438,0.00001755665,0.0002753256,0.9868874,0.0001744693,0.000406035,0.009992391],"study_design_scores_gemma":[0.0003000459,0.01270428,0.01500113,0.00003181892,0.00006939268,0.001461004,0.00006595178,0.004016067,0.9601284,0.0002823742,0.005923931,0.00001563983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941003,0.002369741,0.0008762564,0.0002122614,0.00008218445,0.00004115762,0.0001553407,0.00013925,0.002023513],"genre_scores_gemma":[0.9974313,0.0008277575,0.0004855594,0.0001110717,0.0000297612,0.00004623311,0.0001632467,0.00001092427,0.0008941669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001112223,"threshold_uncertainty_score":0.00372076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013765047830695,"score_gpt":0.2661501953040062,"score_spread":0.2460125448256992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}