{"id":"W4365515216","doi":"10.1080/2162402x.2023.2201147","title":"Neoadjuvant immune checkpoint blockade triggers persistent and systemic T <sub>reg</sub> activation which blunts therapeutic efficacy against metastatic spread of breast tumors","year":2023,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, British Columbia; Ministerie van Volksgezondheid, Welzijn en Sport; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; F. Hoffmann-La Roche; Oncode Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Medicine; Immune checkpoint; Breast cancer; Immune system; Cancer research; Metastatic breast cancer; Metastasis; Primary tumor; Cancer; Immunotherapy; Blockade; Oncology; CD8; Internal medicine; Immunology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006454269,0.0003581289,0.0009404048,0.0004897968,0.0001388966,0.00002017904,0.0001910919,0.0001950008,0.00003065817],"category_scores_gemma":[0.00009390046,0.0003039624,0.000339093,0.001002416,0.0003418329,0.000102205,0.00008634012,0.0003574033,0.00004390863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003102488,"about_ca_system_score_gemma":0.0003216944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002305036,"about_ca_topic_score_gemma":0.00001321696,"domain_scores_codex":[0.9975622,0.0002276056,0.000878944,0.0004797235,0.0003214213,0.000530095],"domain_scores_gemma":[0.9984309,0.000230842,0.0004782406,0.0005802345,0.0001946443,0.00008511307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003248546,0.0002595123,0.0005023511,0.0002568031,0.001465598,0.00003012043,0.001463346,0.00004301763,0.9195918,0.00001512005,0.00003175213,0.073092],"study_design_scores_gemma":[0.01914509,0.002395835,0.3219048,0.002245054,0.000935105,0.002406209,0.007682211,0.001276501,0.640695,0.00003474166,0.0006007339,0.000678702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891769,0.007185785,0.00002268888,0.001908807,0.0003446699,0.0009146265,0.00002842918,0.000155837,0.0002622308],"genre_scores_gemma":[0.9961804,0.003142141,0.00002643394,0.0001280452,0.00004814288,0.00007207392,0.0001282792,0.00006072042,0.0002137552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3214025,"threshold_uncertainty_score":0.9999412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013765047830695,"score_gpt":0.2661501953040062,"score_spread":0.2460125448256992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}