{"id":"W4365515222","doi":"10.3390/ijms24087206","title":"NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"MHC class I; Biology; Cancer immunotherapy; Immunotherapy; MHC class II; Major histocompatibility complex; CIITA; Cancer research; Fusion protein; Cytotoxic T cell; Antigen; Cell biology; Immunology; Immune system; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962088,0.0003522619,0.0002716825,0.0002118783,0.0001046731,0.0002278427,0.000211197,0.0003159269,0.0007271962],"category_scores_gemma":[0.0001028307,0.00009096862,0.0002457258,0.0001807444,0.000221252,0.000153725,0.0001845585,0.0006044463,0.0002182054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003447733,"about_ca_system_score_gemma":0.0001646525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002662272,"about_ca_topic_score_gemma":0.0002770294,"domain_scores_codex":[0.9997527,0.00004384012,0.00002541626,0.00004610646,0.00006955184,0.00006231169],"domain_scores_gemma":[0.9998962,0.00002064256,0.00003014172,0.00001699479,0.000009001913,0.00002693736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004555933,0.00002046363,0.00003662541,0.00001785671,0.000001877057,0.00001506192,0.000005177545,0.00005045335,0.9992175,0.00004646774,0.000015029,0.0005279579],"study_design_scores_gemma":[0.00001656489,0.0003002453,0.0007746194,0.000003255873,0.000009301817,0.0001234206,0.00000572817,0.0006096433,0.9963386,0.00001540047,0.001801162,0.000002115362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901024,0.002685344,0.004672474,0.0001197285,0.00003463099,0.00005843035,0.0002307208,0.0001829027,0.001913384],"genre_scores_gemma":[0.9944116,0.0005498068,0.003010969,0.00003477594,0.00001035109,0.00003682759,0.0004897891,0.00001639353,0.001439425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007271962,"threshold_uncertainty_score":0.002501488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249732435458672,"score_gpt":0.302557165039044,"score_spread":0.2900598406844572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}