{"id":"W4365517014","doi":"10.1158/1538-7445.am2023-ct116","title":"Abstract CT116: First-in-human study of AZD8853, an anti-growth and differentiation factor 15 (GDF15) antibody, in patients (pts) with advanced/metastatic solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Colorectal cancer; Cancer; Cancer research; Bone marrow; Pharmacodynamics; Internal medicine; Oncology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003932177,0.0001698177,0.0004238657,0.0008878501,0.0001111937,0.0000242534,0.0001314406,0.00007004495,0.00006894514],"category_scores_gemma":[0.00008458207,0.0001252498,0.0000257249,0.001224741,0.0001547216,0.000176349,0.00007448339,0.0004759018,0.000005178784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285773,"about_ca_system_score_gemma":0.0001152907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639221,"about_ca_topic_score_gemma":0.001605746,"domain_scores_codex":[0.9976981,0.0001282577,0.0004032297,0.0004413191,0.0008151646,0.0005139009],"domain_scores_gemma":[0.9991592,0.00009702686,0.0000980208,0.0002636974,0.0002109795,0.0001710366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005535258,0.001378641,0.9709672,0.0005419306,0.00008007458,0.000118044,0.002305836,0.00007088719,0.02244502,0.000002692735,0.00003221792,0.001503958],"study_design_scores_gemma":[0.006890946,0.002366063,0.9847844,0.0007040722,0.000020274,0.000001018428,0.002136013,0.0001546438,0.002785979,0.00002293857,0.00000347924,0.0001301296],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982228,0.0001075749,6.086756e-7,0.0001087868,0.00005138451,0.001367691,0.00002478568,0.00002806871,0.00008827858],"genre_scores_gemma":[0.9994375,0.0002735026,0.000007361836,0.000006019301,0.00001892804,0.00006844683,0.00009439646,0.00003520102,0.00005862131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01965905,"threshold_uncertainty_score":0.510754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04782754742602915,"score_gpt":0.4095079670512926,"score_spread":0.3616804196252635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}