{"id":"W4365810227","doi":"10.1111/gbb.12848","title":"Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry community adults","year":2023,"lang":"en","type":"article","venue":"Genes Brain & Behavior","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; University of Waterloo; McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Common Fund; National Institute on Drug Abuse; National Human Genome Research Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; NIH Office of the Director; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health","keywords":"Impulsivity; Heritability; Endophenotype; Big Five personality traits; Personality; Neuroticism; Genome-wide association study; Phenotype; Additive genetic effects; Confounding; Single-nucleotide polymorphism; Psychology; Clinical psychology; Genetics; Medicine; Biology; Cognition; Psychiatry; Genotype; Internal medicine; Gene; Social psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001366232,0.0005067463,0.0005159058,0.0009829079,0.0007896571,0.0007928024,0.0005619788,0.001014851,0.002192697],"category_scores_gemma":[0.003309367,0.0004159303,0.0009553209,0.001400698,0.0004241867,0.0003429884,0.0007198965,0.0005919154,0.0003163739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641914,"about_ca_system_score_gemma":0.0002301264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01035742,"about_ca_topic_score_gemma":0.009330199,"domain_scores_codex":[0.9990841,0.0003033709,0.0001163547,0.0003271786,0.00009017109,0.00007881884],"domain_scores_gemma":[0.998435,0.0004592082,0.0004272375,0.0003563951,0.0001513089,0.000170903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002408555,0.00004207818,0.996051,0.00001173594,0.000257692,0.0001297383,0.000134909,0.0001251491,0.001366038,0.00003575453,0.0001180228,0.001487053],"study_design_scores_gemma":[0.0000129843,0.0000645738,0.9989616,0.000004341227,0.00009241394,0.0001421207,0.00007581152,0.0003925669,0.0001001296,0.00003661467,0.0001119924,0.00000484927],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987704,0.0001059263,0.0003455964,0.00002151017,0.000006060618,0.0000133194,0.0005266559,0.000006184363,0.0002043189],"genre_scores_gemma":[0.9988109,0.00004011096,0.0004145028,0.00002553445,0.000006435152,0.00002146113,0.0005098301,0.00000562905,0.0001655762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01035742,"threshold_uncertainty_score":0.02059424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04982677369903526,"score_gpt":0.3312696930702486,"score_spread":0.2814429193712133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}