{"id":"W4365813711","doi":"10.1007/s00262-023-03442-2","title":"Engineered murine IL-21-secreting leukemia cells induce granzyme B+ T cells and CD4+CD44+CD62L− effector memory cells while suppressing regulatory T cells, leading to long-term survival","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Leukemia and Lymphoma Society of Canada; Leukemia and Lymphoma Society","keywords":"Leukemia; Adoptive cell transfer; Granzyme B; Immunology; Biology; CD8; Immune system; Interleukin 21; Cytotoxic T cell; IL-2 receptor; Granzyme; Cancer research; Molecular biology; T cell; Perforin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001590019,0.001074883,0.001784646,0.001159542,0.0005966949,0.0002062009,0.0008839893,0.0008267947,0.00315329],"category_scores_gemma":[0.00004928084,0.001101054,0.0004251844,0.001490709,0.0007073689,0.0003014004,0.0004284991,0.001792987,0.0005298686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001500865,"about_ca_system_score_gemma":0.0007031315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000453523,"about_ca_topic_score_gemma":0.00004680606,"domain_scores_codex":[0.9936292,0.0006580023,0.001114908,0.001569457,0.0008615885,0.002166881],"domain_scores_gemma":[0.9960973,0.0009422334,0.0003453131,0.001834215,0.000325287,0.00045561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002261938,0.0001127838,0.001179537,0.000444193,0.001078064,0.0002607476,0.002400756,0.0004637243,0.9582749,0.000005211868,0.002106427,0.03141169],"study_design_scores_gemma":[0.007096882,0.0007719738,0.01792353,0.0007469738,0.0001275455,0.00006141473,0.0003051301,0.0001580629,0.9594839,0.000007236692,0.01231056,0.001006825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766282,0.01450991,0.0001403613,0.0004892413,0.004763016,0.002222728,0.0001634465,0.00068916,0.0003939444],"genre_scores_gemma":[0.9592884,0.01467973,0.0003463991,0.0006876109,0.001069816,0.0005297505,0.0001771905,0.0006226149,0.02259846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03040487,"threshold_uncertainty_score":0.999144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02711680003422472,"score_gpt":0.3015848131794638,"score_spread":0.2744680131452391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}