{"id":"W4365815278","doi":"10.1155/2023/1496597","title":"In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay","year":2023,"lang":"en","type":"article","venue":"Stem Cells International","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Ataxia Foundation","keywords":"Induced pluripotent stem cell; Neurofilament; Neurite; Biology; Neuroscience; In vitro; Purkinje cell; Cell biology; Pathology; Medicine; Cerebellum; Gene; Genetics; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990827,0.0002810889,0.0002703497,0.000185359,0.0001258977,0.0002948191,0.0001862128,0.0003515668,0.0007007461],"category_scores_gemma":[0.0001480258,0.0001195194,0.0002710194,0.0001682494,0.0001507628,0.0001372791,0.000165795,0.0003751472,0.0004267071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322363,"about_ca_system_score_gemma":0.0001134748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006301825,"about_ca_topic_score_gemma":0.0009628939,"domain_scores_codex":[0.9998216,0.00002154176,0.00004171972,0.00004582696,0.00005160169,0.00001774057],"domain_scores_gemma":[0.9999,0.00002802458,0.00001718466,0.00001663676,0.00001853616,0.0000195658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004907709,0.0000211579,0.0008236602,0.00006159234,0.00001602944,0.0003939698,0.00008309444,0.0001506467,0.9970013,0.0001157705,0.00002763497,0.001255895],"study_design_scores_gemma":[0.00003530996,0.0007611028,0.03003904,0.0000346197,0.0001424807,0.002564003,0.0001350646,0.002094565,0.9558262,0.0001512317,0.008200778,0.0000156709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800273,0.003583966,0.01053866,0.00008649039,0.00006335507,0.0001242531,0.002039888,0.00009009595,0.00344606],"genre_scores_gemma":[0.9842344,0.001536736,0.006903984,0.00008177966,0.00001343769,0.0001475241,0.004535768,0.00003740922,0.002508911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007007461,"threshold_uncertainty_score":0.002344191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843068108680606,"score_gpt":0.2184112190689819,"score_spread":0.1999805379821758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}