{"id":"W4365815278","doi":"10.1155/2023/1496597","title":"In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay","year":2023,"lang":"en","type":"article","venue":"Stem Cells International","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Ataxia Foundation","keywords":"Induced pluripotent stem cell; Neurofilament; Neurite; Biology; Neuroscience; In vitro; Purkinje cell; Cell biology; Pathology; Medicine; Cerebellum; Gene; Genetics; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00004225146,0.0003312011,0.0003994045,0.0003529667,0.00005704342,0.00006669405,0.0004441788,0.00009265378,0.0001290065],"category_scores_gemma":[0.00002268965,0.0003045064,0.00006753171,0.0004339489,0.0001146417,0.0002390953,0.0002330282,0.0001689726,0.00003736372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005496054,"about_ca_system_score_gemma":0.00006931075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001419276,"about_ca_topic_score_gemma":0.00001918175,"domain_scores_codex":[0.9971098,0.0003331327,0.00067071,0.0008210832,0.0007725405,0.0002927677],"domain_scores_gemma":[0.9984589,0.0002501817,0.0006303682,0.0003069231,0.0002388965,0.000114727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004496895,0.0003221227,0.005684533,0.0000244014,0.00003956655,0.00002091186,0.000288415,0.0003612776,0.9924739,0.000005339444,0.00002772015,0.0003021124],"study_design_scores_gemma":[0.001556238,0.0001395919,0.1211149,0.00007367802,0.00003395832,2.470033e-7,0.0000331365,0.008531033,0.8682781,0.00001152099,0.00001362184,0.0002139499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899253,0.000007082901,0.0001308944,0.00005719665,0.001511301,0.0006552119,0.007655693,0.00004639487,0.00001093055],"genre_scores_gemma":[0.998772,0.00003699668,0.00003355072,0.00009114471,0.00007844012,0.00004503001,0.0005072932,0.00005277516,0.0003827254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1241957,"threshold_uncertainty_score":0.9999407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843068108680606,"score_gpt":0.2184112190689819,"score_spread":0.1999805379821758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}