{"id":"W4366082737","doi":"10.1021/acsami.2c22381","title":"Contact Guidance of Connective Tissue Fibroblasts on Submicrometer Anisotropic Topographical Cues Is Dependent on Tissue of Origin, β1 Integrins, and Tensin-1 Recruitment","year":2023,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Fibrillogenesis; Connective tissue; Fibronectin; Integrin; Nanotopography; Vinculin; Extracellular matrix; Cell biology; Type I collagen; Cell adhesion; Adhesion; Biophysics; Dermal fibroblast; Materials science; Cell; Fibroblast; Cell culture; Biology; Biochemistry; Fibril; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000484682,0.0001184602,0.00008066431,0.00007645556,0.00008267333,0.0001522785,0.0000596977,0.00009638205,0.0006667595],"category_scores_gemma":[0.00006854022,0.00009207024,0.00008276744,0.00007135761,0.00006964718,0.00006690715,0.00009547189,0.0001550141,0.0001429489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113849,"about_ca_system_score_gemma":0.00009182114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098477,"about_ca_topic_score_gemma":0.002556564,"domain_scores_codex":[0.9999247,0.000006861512,0.000004300718,0.0000119372,0.00002808124,0.00002416238],"domain_scores_gemma":[0.999941,0.00001837618,0.00001666624,0.000005118312,0.000007361406,0.00001145652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001485734,0.000003382622,0.0001328625,0.000005536788,3.893843e-7,0.0000147424,0.000009454364,0.00001054082,0.999397,0.000008278021,0.000007576326,0.0003953807],"study_design_scores_gemma":[0.000007622888,0.0001551384,0.03169491,0.000003613319,0.00000464282,0.0002034005,0.00007096201,0.0009591675,0.9660569,0.00002235768,0.0008175515,0.000003871965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985311,0.0003113458,0.0004820317,0.00001289663,0.000003601723,0.000004914889,0.00004907955,0.00000720578,0.0005977463],"genre_scores_gemma":[0.9980736,0.0002379009,0.000779943,0.00001508427,0.000002675926,0.00001009345,0.00008598204,0.000002203955,0.0007925492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001098477,"threshold_uncertainty_score":0.002230585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741691897186121,"score_gpt":0.298940448684778,"score_spread":0.2715235297129168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}