{"id":"W4366083334","doi":"10.1016/j.jtha.2023.04.005","title":"What’s fishy about protamine? Clinical use, adverse reactions, and potential alternatives","year":2023,"lang":"en","type":"review","venue":"Journal of Thrombosis and Haemostasis","topic":"Heparin-Induced Thrombocytopenia and Thrombosis","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; Octapharma; Japan Blood Products Organization","keywords":"Protamine; Heparin; Medicine; Protamine sulfate; Dosing; Cardiopulmonary bypass; Anticoagulant; Pharmacology; Pharmacokinetics; Anesthesia; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001150577,0.0006412428,0.002313581,0.001588811,0.0002383516,0.001582702,0.0008554115,0.001989103,0.003236649],"category_scores_gemma":[0.002609113,0.0002990114,0.001090654,0.001446616,0.0007230475,0.001922399,0.0004302793,0.002759359,0.000954633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004388437,"about_ca_system_score_gemma":0.001175012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001395305,"about_ca_topic_score_gemma":0.003669591,"domain_scores_codex":[0.999529,0.0001261991,0.0001117263,0.00006422413,0.0001421115,0.00002665038],"domain_scores_gemma":[0.9985506,0.0008741261,0.0002557703,0.00003058009,0.0002265453,0.00006237266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002852201,0.00006007205,0.000279816,0.03588617,0.0003832057,0.0002948771,0.00007563766,0.0002062435,0.00090503,0.002248678,0.03534346,0.9240317],"study_design_scores_gemma":[0.0002687803,0.0004011749,0.001878986,0.03130287,0.0009750805,0.003424933,0.0002044915,0.0002242916,0.0004028768,0.00302976,0.957826,0.00006078043],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005709805,0.9989439,0.00002928529,0.0005801309,0.000209611,0.000002128447,0.000009057429,0.000001697443,0.0001671133],"genre_scores_gemma":[0.0006880632,0.9974861,0.0001070763,0.0009964666,0.0005176876,0.000004467144,0.00001392879,0.000001034091,0.0001850472],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003236649,"threshold_uncertainty_score":0.01082766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3365548802038882,"score_gpt":0.4778886121789305,"score_spread":0.1413337319750423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}